... by cell proliferation, in coordination with the Notch signaling pathway, are essential for the formation of epithelial folds in precise locations along the proximo-distal axis of the leg. As cell numbers increase, compressive stresses arise, promoting the folding of the epithelium and reinforcing...

...Melisa A. Fuentes; Bing He ABSTRACT Epithelial folding mediated by apical constriction serves as a fundamental mechanism to convert flat epithelial sheets into multilayered structures. It remains unknown whether additional mechanical inputs are required for apical constriction-mediated folding...

...Liyuan Sui; Christian Dahmann ABSTRACT The folding of epithelial sheets is important for tissues, organs and embryos to attain their proper shapes. Epithelial folding requires subcellular modulations of mechanical forces in cells. Fold formation has mainly been attributed to mechanical force...

... results in basal relaxation and the formation of an epithelial fold. Here, we show that Wingless, which is expressed next to this fold, promotes basal cell edge tension to suppress the formation of this fold. Ectopic expression of Wingless blocks fold formation, whereas the depletion of Wingless increases...

... during a complex epithelial folding event in the early Drosophila embryo. We expect this tool to be broadly useful for the analysis of epithelial cell geometries and movements in a wide variety of developmental contexts. * Authors for correspondence ( [email protected] ; [email protected]...

...Zvi Kam; Jonathan S. Minden; David A. Agard; John W. Sedat; Maria Leptin ABSTRACT The first event of Drosophila gastrulation is the formation of the ventral furrow. This process, which leads to the invagination of the mesoderm, is a classical example of epithelial folding. To understand better...

... of the epithelial foldings associated with the apical contraction model ( Odell et al . 1981 ) as well as many deformations that apical contraction alone cannot produce. (For example, the cuboidal-to-columnar transitions characterizing placode formation which precede most foldings cannot easily be generated...