...Murugesan Pooranachithra; Erin M. Jyo; Nicolas Brouilly; Nathalie Pujol; Andreas M. Ernst; Andrew D. Chisholm ABSTRACT The apical extracellular matrix (aECM) of external epithelia often contains lipid-rich outer layers that contribute to permeability barrier function. The external aECM of nematodes...

... in delayed embryonic lethality, partial tissue fusion rescue, and restoration of tissue form within the craniofacial epithelia. These data suggest that aberrant epithelial maintenance, partially regulated by noggin-mediated regulation of BMP-SMAD pathways, may underpin tissue fusion defects in Grhl2 −/− mice...

... of cell extrusion/cell death events in large movies of epithelia marked with cell contour. The pipeline, initially trained on movies of the Drosophila pupal notum marked with fluorescent E-cadherin, is easily trainable, provides fast and accurate extrusion predictions in a large range of imaging...

... typically powered by the contractile actomyosin cytoskeleton. This has been investigated mainly in homogeneous epithelia, where intercalation takes minutes. However, in some tissues, intercalation involves different cell types and can take hours. Whether slow and fast intercalation share the same mechanisms...

... of liposomes ( Caorsi et al., 2016 ), or a few cells ( Brodland et al., 2010 ), a 2D section through a symmetry plane, or a fit of cell shape with a sphere, simplifies the analysis. In 3D monolayered epithelia, such as in Drosophila germband ( Chiou et al., 2012 ; Kong et al., 2019 ; McCleery et al., 2019...

...Benoit Aigouy; Claudio Cortes; Shanda Liu; Benjamin Prud'Homme ABSTRACT Epithelia are dynamic tissues that self-remodel during their development. During morphogenesis, the tissue-scale organization of epithelia is obtained through a sum of individual contributions of the cells constituting...

... to have been completely repaired ( Fig. S3B ). This repair was also accompanied by transient caspase 3-activating cells. As these cells appeared from the neighboring epithelia, which was previously located almost 1-10 cells away from the wounded site ( Fig. S3C ), we assumed that caspase 3 activation...

... , J. , Mandai , K. , Ishizaki , H. , Tanaka , M. , Togawa , A. , Takahashi , K. , Nishioka , H. , Yoshida , H. , et al. ( 1999 ). Afadin: a key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis . J. Cell...

... Ltd 2017 http://www.biologists.com/user-licence-1-1/ Summary: Single-cell sequencing combined with a battery of molecular tools reveals novel features of cellular dynamics and differentiation during lacrimal gland development in mice. Lacrimal gland Epithelia Single cell...

... question is how apical contractility must be spatially patterned in a tissue to generate three-dimensional (3D) form. American Cancer Society 10.13039/100000048 125792-RSG-14-039-01-CSM National Institutes of Health 10.13039/100000002 R01GM105984 Epithelia Fold...

... epithelial remodeling in various species. Image segmentation Cell tracking Planar polarity Epithelia Morphogenesis Convergent extension Drosophila Changes in epithelial organization are essential for tissue development, regeneration and repair. Advances in microscopy have made...

... is not required in the wing disc because there are parallel mechanisms for Mud localization and hence spindle orientation, making it a more robust system than in other epithelia. * Present address: Department of Biology, University of Rochester, Rochester, NY 14627, USA. ‡ Present address: Faculty...

...Myrto Deligiannaki; Abbie L. Casper; Christophe Jung; Ulrike Gaul Epithelial sheets play essential roles as selective barriers insulating the body from the environment and establishing distinct chemical compartments within it. In invertebrate epithelia, septate junctions (SJs) consist of large...

... show that loss of Cα, the predominant C-terminal p63 variant in epithelia, promotes the transcriptional activity of TAp63 and also impairs the dominant-negative activity of ΔNp63, thereby controlling p21 Waf1/Cip1 expression. We propose that the p63 C-terminus links cell cycle control...

.... D. ( 2001 ). Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia . Nat. Cell Biol. 3 , 983 - 991 . 10.1038/ncb1101-983 Liegeois , S. , Benedetto , A. , Michaux , G. , Belliard , G. and Labouesse , M. ( 2007 ). Genes...

...Lara C. Skwarek; Sarah L. Windler; Geert de Vreede; Gregory C. Rogers; David Bilder The Par-3/Par-6/aPKC complex is the primary determinant of apical polarity in epithelia across animal species, but how the activity of this complex is restricted to allow polarization of the basolateral domain...

... no competing financial interests. 11 11 2013 13 5 2014 © 2014. Published by The Company of Biologists Ltd 2014 Drosophila Endocytosis Epithelia Polarity Retromer The polarized distribution of proteins is central to biological function. Foundational work has identified...

...Sonia Hall; Courtney Bone; Kenzi Oshima; Liang Zhang; Molly McGraw; Bethany Lucas; Richard G. Fehon; Robert E. Ward, IV Polarized epithelia play crucial roles as barriers to the outside environment and enable the formation of specialized compartments for organs to carry out essential functions...

... tubes of specific sizes and shapes, it is not surprising that their development and maintenance can go awry and cause devastating diseases. Tubulogenesis Endothelia Epithelia Morphogenesis Lumen © 2013. Published by The Company of Biologists Ltd 2013 Competing interests...

... ovarian follicular epithelia . Development 130 , 1927 – 1935 . Adams A. E. , Johnson D. I. , Longnecker R. M. , Sloat B. F. , Pringle J. R. ( 1990 ). CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast...