...Viktória Halasy; Emőke Szőcs; Ádám Soós; Tamás Kovács; Nóra Pecsenye-Fejszák; Ryo Hotta; Allan M. Goldstein; Nándor Nagy ABSTRACT The gastrointestinal tract is innervated by an intrinsic neuronal network, known as the enteric nervous system (ENS), and by extrinsic axons arising from peripheral...

...Rhian Stavely; Ryo Hotta; Richard A. Guyer; Nicole Picard; Ahmed A. Rahman; Meredith Omer; Adam Soos; Emoke Szocs; Jessica Mueller; Allan M. Goldstein; Nandor Nagy ABSTRACT Enteric nervous system development relies on intestinal colonization by enteric neural crest-derived cells (ENCDCs...

...Phillip A. Baker; Rodrigo Ibarra-García-Padilla; Akshaya Venkatesh; Eileen W. Singleton; Rosa. A. Uribe ABSTRACT The enteric nervous system is a vast intrinsic network of neurons and glia within the gastrointestinal tract and is largely derived from enteric neural crest cells (ENCCs) that emigrate...

... various pharmacological inhibitors and BAPX1 gene overexpression in vivo . We found that the enteric nervous system determines the onset of the synchronized contractions in the stomach. Moreover, alteration of smooth muscle fiber organization led to an impairment of this functional activity. Altogether...

...Nandor Nagy; Tamas Kovacs; Rhian Stavely; Viktoria Halasy; Adam Soos; Emoke Szocs; Ryo Hotta; Hannah Graham; Allan M. Goldstein ABSTRACT The enteric nervous system (ENS), which is derived from enteric neural crest cells (ENCCs), represents the neuronal innervation of the intestine. Compromised ENCC...

... findings and discuss how the esophagus is established and matures throughout different stages, including its initial specification, respiratory-esophageal separation, epithelial morphogenesis and maintenance. We also discuss esophageal muscular development and enteric nervous system innervation, which...

... embryonic development to assure proper gut function, specifically addressing the spatiotemporal and key molecular aspects along the longitudinal and circumferential axes of the gut. Gut Enteric nervous system Intrinsic innervation Extrinsic innervation Proper function...

... colonic aganglionosis and intestinal ganglioneuromas. Interestingly, the tumors induced by GDNF stimulation contain enteric neuronal progenitors capable of reconstituting an enteric nervous system when transplanted into a normal developmental environment. These results suggest that a Janus mutation may...

...Wael Noor El-Nachef; Marianne E. Bronner ABSTRACT The enteric nervous system (ENS) is essential for normal gastrointestinal function. Although the embryonic origin of enteric neurons from the neural crest is well established, conflicting evidence exists regarding postnatal enteric neurogenesis...

...Nandor Nagy; Csilla Barad; Ryo Hotta; Sukhada Bhave; Emily Arciero; David Dora; Allan M. Goldstein ABSTRACT The enteric nervous system (ENS) arises from neural crest cells that migrate, proliferate, and differentiate into enteric neurons and glia within the intestinal wall. Many extracellular...

...Logan Myers; Hiran Perera; Michael G. Alvarado; Thomas Kidd ABSTRACT The RET receptor tyrosine kinase is crucial for the development of the enteric nervous system (ENS), acting as a receptor for Glial cell line-derived neurotrophic factor (GDNF) via GFR co-receptors. Drosophila has a well-conserved...

... and enteric nervous system development by, at least in part, directly controlling the expression of the key early regulators of NC ontogenesis Pax3 , Msx1 and Foxd3 . Our work thus reveals a novel role for Cdx proteins at the top of the trunk NC gene regulatory network in the mouse, which appears to have been...

...Nandor Nagy; Csilla Barad; Hannah K. Graham; Ryo Hotta; Lily S. Cheng; Nora Fejszak; Allan M. Goldstein The enteric nervous system (ENS) develops from neural crest cells that migrate along the intestine, differentiate into neurons and glia, and pattern into two plexuses within the gut wall...

..., Chuo-ku, 650-0047 Kobe, Japan. Competing interests statement 30 12 2009 © 2010. Embryonic stem cells Enteric nervous system Neural crest Mouse Neural crest cells emerge from the dorsal margin of the neural plate and produce a wide variety of cell types...

...Ming Fu; Yoshiharu Sato; Ariel Lyons-Warren; Bin Zhang; Maureen A. Kane; Joseph L. Napoli; Robert O. Heuckeroth Hirschsprung disease is a serious disorder of enteric nervous system (ENS) development caused by the failure of ENS precursor migration into the distal bowel. We now demonstrate...

..., A., de Graaff, E. and Pachnis, V. ( 2003 ). Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET. Neuron 40 , 905 -916. Beauvais-Jouneau, A., Delouvée, A., Craig, S. E.,Humphries, M. J., Thiery, J. P...

... and colonises the entire gastrointestinal tract to form the enteric nervous system(ENS). The colonisation of embryonic gut by NCCs has been studied extensively in chick embryos, and genetic studies in mice have identified genes crucial for ENS development, including Ret . Here, we have combined mouse embryo...

...Amanda J. Barlow; Adam S. Wallace; Nikhil Thapar; Alan J. Burns The enteric nervous system (ENS) is mainly derived from vagal neural crest cells (NCC) that arise at the level of somites 1-7. To understand how the size and composition of the NCC progenitor pool affects ENS development, we reduced...

.... ( 1985 ). Combined immunostaining of neurofilaments, neuron specific enolase, GFAP, and S-100. A possible method for assessing the morphological and functional status of the enteric nervous system. Histochemistry 82 , 93 -97. Blaugrund, E., Pham, T. D., Tennyson, V. M., Lo, L., Sommer, L...

...Naoya Asai; Toshifumi Fukuda; Zaiqi Wu; Atsushi Enomoto; Vassilis Pachnis; Masahide Takahashi; Frank Costantini The RET receptor tyrosine kinase plays a critical role in the development of the enteric nervous system (ENS) and the kidney. Upon glial-cell-line-derived neurotrophic factor (GDNF...