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Keywords: enhancers
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Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2024) 151 (9): dev202525.
Published: 9 May 2024
... evolutionary conservation and chromatin accessibility to identify enhancers located in the proximity of zebrafish prox1a active in developing LECs. We confirmed the functional role of the identified sequences through CRISPR/Cas9 mutagenesis of a lymphatic valve enhancer. The deletion of this region results...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (23): dev202166.
Published: 27 November 2023
... enhancer limits regeneration in mature Drosophila imaginal discs . eLife 5 , e11588 . 10.7554/eLife.11588 Hartupee , J. and Mann , D. L. ( 2017 ). Neurohormonal activation in heart failure with reduced ejection fraction . Nat. Rev. Cardiol. 14 , 30 - 38 . 10.1038/nrcardio...
Journal Articles
Journal: Development
Development (2023) 150 (12): dev201546.
Published: 20 June 2023
.... There is a large body of evidence that suggests the bursts are actively modulated by transcriptional machinery and play a role in regulating developmental processes. Under a commonly used two-state model of transcription, various enhancer-, promoter- and chromatin microenvironment-associated features are found...
Journal Articles
Journal: Development
Development (2022) 149 (16): dev200398.
Published: 30 August 2022
...Laura J. Harrison; Daniel Bose ABSTRACT Enhancers confer precise spatiotemporal patterns of gene expression in response to developmental and environmental stimuli. Over the last decade, the transcription of enhancer RNAs (eRNAs) – nascent RNAs transcribed from active enhancers – has emerged...
Journal Articles
Journal: Development
Development (2022) 149 (12): dev200594.
Published: 30 June 2022
... their target genes through higher-order chromatin structures. However, how such architectures and variations in CREs contribute to transcriptional evolvability remains elusive. We use Hoxd genes as a paradigm for the emergence of regulatory innovations, as many relevant enhancers are located in a regulatory...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (11): dev186536.
Published: 10 June 2022
...Tomás Pachano; Endika Haro; Alvaro Rada-Iglesias ABSTRACT Enhancers control the establishment of spatiotemporal gene expression patterns throughout development. Over the past decade, the development of new technologies has improved our capacity to link enhancers with their target genes based...
Journal Articles
Journal: Development
Development (2022) 149 (2): dev200118.
Published: 20 January 2022
... expression profiles during development. Chromatin Development Enhancers Global repression Epigenetics Pioneer factors Israel Science Foundation http://dx.doi.org/10.13039/501100003977 Rosetrees Trust http://dx.doi.org/10.13039/501100000833 Israel Cancer Research...
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (6): dev197202.
Published: 15 March 2021
...Ivelisse Cajigas; Abhijit Chakraborty; Madison Lynam; Kelsey R. Swyter; Monique Bastidas; Linden Collens; Hao Luo; Ferhat Ay; Jhumku D. Kohtz ABSTRACT The Evf2 long non-coding RNA directs Dlx5/6 ultraconserved enhancer( UCE )-intrachromosomal interactions, regulating genes across a 27 Mb region...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (19): dev179523.
Published: 30 September 2019
...Iain Williamson; Lauren Kane; Paul S. Devenney; Ilya M. Flyamer; Eve Anderson; Fiona Kilanowski; Robert E. Hill; Wendy A. Bickmore; Laura A. Lettice ABSTRACT Topologically associating domains (TADs) have been proposed to both guide and constrain enhancer activity. Shh is located within a TAD known...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (14): dev178285.
Published: 25 July 2019
... the cis -regulatory sequences that control dsx expression in the foreleg, which contains multiple types of sex-specific sensory organs. We find that separate modular enhancers are responsible for dsx expression in each sexually dimorphic organ. Expression of dsx in the sex comb is co-regulated by two...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3646–3658.
Published: 15 October 2017
...Guillaume Andrey; Stefan Mundlos The precise expression of genes in time and space during embryogenesis is largely influenced by communication between enhancers and promoters, which is propagated and governed by the physical proximity of these elements in the nucleus. Here, we review how chromatin...
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (8): 1418–1430.
Published: 15 April 2015
... understood. Here, we show that the chromatin remodeling factor Brg1 is required for enhancer activation in mesoderm induction. In an embryonic stem cell-based directed differentiation assay, the absence of Brg1 results in a failure of cardiomyocyte differentiation and broad deregulation of lineage-specific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (20): 3934–3943.
Published: 15 October 2014
...Eve Anderson; Paul S. Devenney; Robert E. Hill; Laura A. Lettice Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms. The Shh gene and well-established regulators...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1457–1466.
Published: 15 April 2012
... that generally involves transcriptional regulation mediated by multiple separate enhancers, each with its own arrangement of transcription factor (TF)-binding sites and associated activities. Here, by contrast, we show that the expression of the Drosophila Nidogen ( Ndg ) gene at different embryonic stages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (10): 2387–2394.
Published: 15 May 2004
...Michele Markstein; Robert Zinzen; Peter Markstein; Ka-Ping Yee; Albert Erives; Angela Stathopoulos; Michael Levine Bioinformatics methods have identified enhancers that mediate restricted expression in the Drosophila embryo. However, only a small fraction of the predicted enhancers actually work...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (1996) 122 (2): 543–554.
Published: 1 February 1996
... gene with particular focus on r3 and r5 in wild type and Krox-20 −/− mutant embryos. There was a clear loss of expression in r3, which indicated that Hoxa-2 was downstream of Krox-20 . Using transgenic analysis with E. coli lacZ reporter genes we have identified and mapped an r3/r5 enhancer in the 5...