...Asra Almubarak; Qiuwan Zhang; Cheng-Hai Zhang; Noor Abdelwahab; Tsutomu Kume; Andrew B. Lassar; Fred B. Berry ABSTRACT The Forkhead box transcription factors FOXC1 and FOXC2 are expressed in condensing mesenchyme cells at the onset of endochondral ossification. We used the Prx1-cre mouse to ablate...

...Elham Koosha; Connor T. A. Brenna; Amir M. Ashique; Niteesh Jain; Katie Ovens; Toshiyasu Koike; Hiroshi Kitagawa; B. Frank Eames ABSTRACT During endochondral ossification, chondrocytes secrete a proteoglycan (PG)-rich extracellular matrix that can inhibit the process of cartilage maturation...

...Sho Tsukamoto; Mai Kuratani; Shinya Tanaka; Eijiro Jimi; Hiromi Oda; Takenobu Katagiri ABSTRACT Endochondral ossification contributes to longitudinal skeletal growth. Osteoblasts, which are bone-forming cells, appear close to terminally differentiated hypertrophic chondrocytes during endochondral...

... activity causes craniosynostosis. Constitutive activation of PDGFRα leads to expansion of cartilage underlying the coronal sutures, which contribute to suture closure through endochondral ossification, in a process regulated in part by PI3K/AKT signaling. Our results thus identify a novel mechanism...

...: Attenuation of glucose consumption in Igf2 null mice rescued the mutant phenotype of premature cartilage maturation, revealing that IGF2 controls cartilage development in part by regulating glucose metabolism in chondrocytes. IGF2 Postnatal Cartilage Growth plate Endochondral ossification Glucose...

...Diane P. Hu; Federico Ferro; Frank Yang; Aaron J. Taylor; Wenhan Chang; Theodore Miclau; Ralph S. Marcucio; Chelsea S. Bahney ABSTRACT Fractures heal predominantly through the process of endochondral ossification. The classic model of endochondral ossification holds that chondrocytes mature...

...Stephen Tonna; Ingrid J. Poulton; Farzin Taykar; Patricia W. M. Ho; Brett Tonkin; Blessing Crimeen-Irwin; Liliana Tatarczuch; Narelle E. McGregor; Eleanor J. Mackie; T. John Martin; Natalie A. Sims The majority of the skeleton arises by endochondral ossification, whereby cartilaginous templates...

... for correspondence ([email protected]) Competing interests statement The authors declare no competing financial interests. 6 1 2011 © 2011. 2011 Endochondral ossification Pten Perichondrium FGF18 Dermo1 cre Osteoprogenitors Mouse Endochondral ossification is the process...

... the formation of a mammalian digit blastema. Unlike the endogenous regeneration response that involves redifferentiation by direct ossification (evolved regeneration), the BMP-induced response involves endochondral ossification (redevelopment). Our evidence suggests that BMP treatment triggers a reprogramming...

... to severe skeletal defects, including delayed ossification and low bone mass, short stature and short limbs. Atf4 is expressed in proliferative and prehypertrophic growth plate chondrocytes, suggesting an autonomous function of Atf4 in chondrocytes during endochondral ossification. In Atf4 −/− growth plate...

...) 22 4 2003 © 2003. 2003 Matrix metalloproteinase 9 Vascular endothelial growth factor Endochondral ossification Cartilage Bone healing Mechanical environment Mouse The bony skeleton possesses an astounding regenerative potential. Unlike other adult tissues, which generate...

... to an equivalent coordinated expression and localization of their two splice variants (Kettunen et al., 1998 ; Beer et al., 2000). Transcriptional alternatives FGF Endochondral ossification Craniosynostosis Gene targeting Mouse © 2002. 2002 17 5 2002 *Author for correspondence (e...

...Eleonora Minina; Hans Markus Wenzel; Conny Kreschel; Seth Karp; William Gaffield; Andrew P. McMahon; Andrea Vortkamp During endochondral ossification, two secreted signals, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP), have been shown to form a negative feedback loop...

... © 1992 by Company of Biologists 1992 endochondral ossification cartilage TGF- β bone chicken type II collagen chondrocyte osteoblast osteoclast The growth and maintenance of the skeleton is controlled by interactions between the cells that form cartilage and bone...