... origin and function of extra-embryonic mesoderm in vertebrates from in vivo studies. Extra-embryonic mesoderm Embryonic development Model organisms Evolution Stem cell-based embryo models Fonds De La Recherche Scientifique – FNRS Fonds Wetenschappelijk Onderzoek http...

...Mark Peifer ABSTRACT Our current understanding of the molecular basis of embryonic development and the shared machinery underlying this remarkable process has its roots in three papers published 40 years ago, which summarize the results of the Nobel Prize-winning ‘Heidelberg screen’. The genesis...

... before formation of the dermal condensate. Hair follicle Induction Embryonic development Tissue recombination R-spondin Bmp Mouse Sigrid Juséliuksen Säätiö http://dx.doi.org/10.13039/501100006306 Helsingin Yliopisto http://dx.doi.org/10.13039/100007797...

... the regenerative mechanisms required to replenish the lost tissue following injury ( Fig. 2 ). In this Review, we have summarized our current understanding of metabolic switches and their roles in embryonic development, postnatal development, cell fate decisions and tissue regeneration. We further...

... that is dictated by their tightly linked genomic organization. Although their genetic function during embryonic development has been interrogated, less is known about how these transcription factors regulate downstream genes to direct morphogenetic events. Moreover, the continued expression and function of Hox...

... to suppress transcription of eef1a1l2 . Translational control Oogenesis Nanog Zebrafish Embryonic development National Natural Science Foundation of China http://dx.doi.org/10.13039/501100001809 32025037 31702323 32273134 Chinese Academy of Sciences http://dx.doi.org...

...Yinan Zhao; Dandan Bai; You Wu; Dan Zhang; Mengying Liu; Yingpu Tian; Jinhua Lu; Haibin Wang; Shaorong Gao; Zhongxian Lu ABSTRACT How maternal Ezh1 and Ezh2 function in H3K27 methylation in vivo in pre-implantation embryos and during embryonic development is not clear. Here, we have deleted Ezh1...

... induce a graded response within such domains. Drosophila Embryonic Development Gastrulation Morphogen Transcription Weizmann Institute of Science http://dx.doi.org/10.13039/501100001735 United States-Israel Binational Science Foundation 2015063 Weizmann...

... at the single-cell level and establishment of patterns at the tissue-wide level. Here, we emphasize that the general principles of embryonic development and tissue homeostasis are similar, and argue that interactions between these disciplines will be beneficial for both research fields. * These authors...

...Ashley V. Schwartz; Karilyn E. Sant; Julian Navarrete; Uduak Z. George ABSTRACT Optimal embryonic development plays a major role in the health of an individual beyond the developmental stage. Nutritional perturbation during development is associated with cardiovascular and metabolic disease later...

... to the first developing molar is an early signaling center, the molar initiation knot (IK), which is required for the progression of mammalian molar tooth development. Cell division Migration Embryonic development Tooth Signaling center Wnt Shh In recent years, advances in 3D and live...

... a standard protocol. The primers used to clone the sgRNAs have been previously described ( De Iaco et al., 2017 ). In summary, the present work confirms that DUX promotes murine embryonic development. In spite of also surprisingly demonstrating that this factor is not absolutely essential...

... reasonable. Therefore, more studies are needed to reveal whether Hh signalling regulates asymmetric Dand5 expression or Nodal expression in species in addition to amphioxus in the future. The Hh signalling pathway is one of the key pathways that is essential for metazoan embryonic development. Its...

... of protein function with the precision of a pulse of laser light. This Primer gives an overview of the most commonly used optogenetic tools and their application in developmental biology. Embryonic development Optogenetics Signaling Synthetic biology Tissue morphogenesis Optogenetics...

... to active H3K9me3/2 demethylation in in vitro fertilized (IVF) embryos and are deficiently expressed in cloned embryos at the time of EGA. Moreover, KDM4E plays a more crucial role in IVF and SCNT embryonic development, and overexpression of KDM4E can restore the global transcriptome, improve blastocyst...

...Guangwei Hu; Guang Li; Hui Wang; Yiquan Wang Correct patterning of left-right (LR) asymmetry is essential during the embryonic development of bilaterians. Hedgehog (Hh) signaling is known to play a role in LR asymmetry development of mouse, chicken and sea urchin embryos by regulating Nodal...

... available illustrations of developing Xenopus laevis , drawn by Natalya Zahn, provide a resource for teaching and research, especially in the field of craniofacial biology. Xenopus laevis Embryonic development Stage series Craniofacial patterning Eunice Kennedy Shriver National...

... in regulating Prox1 high lymphatic valve-forming EC reorientation and lymphatic valve formation during embryonic development. Although Sdc4 null mice can survive to adulthood, abnormal lymphatic valves were also observed in dermal lymphatic vessels of Sdc4 −/− adults ( Fig. S4C,D ). To establish...

... during fertilization and preimplantation embryonic development. Germline-specific Dicer and Drosha conditional knockout (cKO) mice produce gametes (i.e. sperm and oocytes) partially deficient in miRNAs and/or endo-siRNAs, thus providing a unique opportunity for testing whether normal sperm (paternal...

...Alexander R. Langley; James C. Smith; Derek L. Stemple; Steven A. Harvey The initial phases of embryonic development occur in the absence of de novo transcription and are instead controlled by maternally inherited mRNAs and proteins. During this initial period, cell cycles are synchronous and lack...