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Keywords: embryo
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Journal Articles
Journal: Development
Development (2022) 149 (15): dev200331.
Published: 29 July 2022
... of the mechanistic underpinnings of neuroblastoma. Embryo Epithelial-to-mesenchymal transition Neural crest Neuroblastoma European Social Fund http://dx.doi.org/10.13039/501100004895 MIS 5033021 State Scholarships Foundation http://dx.doi.org/10.13039/501100003447...
Journal Articles
Journal: Development
Development (2022) 149 (14): dev200356.
Published: 14 July 2022
.../by/4.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Highlighted Article: A new open-access Normal Table of Xenopus development is presented that integrates new embryo images with gene expression markers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (11): dev200854.
Published: 6 June 2022
... reprogramming contributes significantly to the dynamic gene expression during ZGA; however, the mechanism has yet to be resolved. Here, we find histone deacetylases 1 and 2 (HDAC1/2) can regulate ZGA through lysine deacetylase activity. Notably, in mouse embryos, overexpression of a HDAC1/2 dominant-negative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (10): dev200351.
Published: 26 May 2022
...Ming-Zhe Dong; Ying-Chun Ouyang; Shi-Cai Gao; Xue-Shan Ma; Yi Hou; Heide Schatten; Zhen-Bo Wang; Qing-Yuan Sun ABSTRACT Mammalian early embryo cells have complex DNA repair mechanisms to maintain genomic integrity, and homologous recombination (HR) plays the main role in response to double-strand...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (7): dev198341.
Published: 14 April 2022
... reproduction. Despite our knowledge of mitotic mis-segregation in somatic cells, the molecular pathways regulating chromosome fidelity during the error-prone cleavage-stage of mammalian embryogenesis remain largely undefined. Using bovine embryos and live-cell fluorescent imaging, we observed frequent micro...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev199743.
Published: 23 March 2022
... to implantation. Unfortunately, our understanding of these key processes for embryo survival is limited because current culture systems cannot sustain ungulate embryo development beyond hatching . Here, we report a culture system that recapitulates most developmental landmarks of gastrulating ovine embryos...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (24): dev200191.
Published: 21 December 2021
... and transcriptome analyses of two-cell embryos revealed that, although ZGA took place, there were subtle defects in embryos that lacked maternal Dppa2/4. Strikingly, heterozygous offspring that inherited the null allele maternally had higher preweaning lethality than those that inherited the null allele paternally...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev200059.
Published: 15 December 2021
... is the prime organizing center for axial elongation in mouse embryos. The T-box transcription factor brachyury (T) is essential for both formation of the notochord and maintenance of NMPs, and thus is a key regulator of trunk and tail development. The T promoter controlling T expression in NMPs and nascent...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2021) 148 (13): dev199589.
Published: 6 July 2021
... surrounding non-embryonic tissues . We have coupled fluorescence-activated nuclei sorting together with single-nucleus mRNA-sequencing to construct a gene expression atlas of Arabidopsis thaliana early embryos at single-cell resolution. In addition to characterizing cell-specific transcriptomes, we found...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (8): dev198150.
Published: 16 April 2021
... determination occurs after PGC colonization of the gonads, and that germ cell tumors reflect a failure of this process. Determination Embryo Germ cell tumor Germline Potency Primordial germ cell The germline is the cell lineage, from zygote to gamete, with the capacity or potential...
Journal Articles
Journal: Development
Development (2021) 148 (18): dev192955.
Published: 24 March 2021
...-computed tomography (micro-CT), have been incorporated into the high-throughput embryo pipeline of the International Mouse Phenotyping Consortium (IMPC). This project generates large volumes of raw data that cannot be immediately exploited without significant resources of personnel and expertise. Thus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (6): dev189217.
Published: 15 March 2021
... marks a stage of developmental divergence between key model organisms, and thus potential variance in the cell and molecular mechanisms for PGC specification. In humans, PGC specification is very difficult to study in vivo . To address this, the combined use of human and nonhuman primate embryos...
Journal Articles
Journal: Development
Development (2021) 148 (5): dev188490.
Published: 12 March 2021
... and developmental functions of TGFβ family proteins. BMP Development Embryo Nodal TGFβ Transforming growth factor β (TGFβ) was first discovered in the late 1970s as a secreted polypeptide growth factor with the ability to transform mammalian fibroblasts ( Moses et al., 2016 ). Since...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev190728.
Published: 30 November 2020
... activity. Here, we establish an inactive mR3-based non-engineered mR3/dsRNA system for RNA tracking in zebrafish embryos. In vitro binding experiments show that inactive Staphylococcus epidermidis mR3 (dSmR3) protein possesses the highest binding affinity with dsRNAs among mR3s from other related species...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev175596.
Published: 28 May 2020
... Embryo Migration Adhesion Differentiation Biophysical The extracellular matrix (ECM) is essential for metazoan life; without it, we would be merely an amorphous mass of cells. The ECM is the non-cellular component of all tissues, forming the physical environment surrounding cells, and playing...
Journal Articles
Journal: Development
Development (2020) 147 (9): dev188821.
Published: 6 May 2020
...Lara Busby; Cristina Aceituno; Caitlin McQueen; Constance A. Rich; Maria A. Ros; Matthew Towers ABSTRACT Classical tissue recombination experiments performed in the chick embryo provide evidence that signals operating during early limb development specify the position and identity of feathers. Here...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2020) 147 (8): dev186130.
Published: 20 April 2020
... specification, growth, pattern formation and cell-type differentiation. Although later developmental steps are understood in some detail, it is still largely unknown how the tissue is initially specified. We used the early Arabidopsis embryo as a simple model to study this process. Using a large collection...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (1): dev183095.
Published: 3 January 2020
... governing ethical considerations of human embryonic research have allowed us to enlighten this black box. Here, we will summarize the current knowledge of human XCI, mainly based on the analyses of embryos derived from in vitro fertilization and of pluripotent stem cells, and highlight any unanswered...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (22): dev181925.
Published: 25 November 2019
..., play key roles in the regulation of cellular lipid metabolism. Although it is well known that mammalian oocytes and embryos contain LDs and that the amount of LDs varies among animal species, their physiological functions remain unclear. In this study, we have developed a method based on two-step...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev151837.
Published: 1 October 2019
... the initial discoveries in the senescence field were made in the areas of cancer and aging, and how more recent discoveries in development and regeneration have helped to reshape our understanding of senescence biology. Senescence Embryo Regeneration Aging Plasticity SASP Cellular...