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Keywords: dorsal
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Journal Articles
Journal: Development
Development (2018) 145 (9): dev156018.
Published: 25 April 2018
... ). Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product . Cell   42 , 791 - 798 . 10.1016/0092-8674(85)90275-2 Anderson , K. V. , Jurgens , G. and Nusslein-Volhard , C. ( 1985b ). Establishment of dorsal-ventral polarity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4450–4461.
Published: 1 December 2017
...Sophia N. Carrell; Michael D. O'Connell; Thomas Jacobsen; Amy E. Pomeroy; Stephanie M. Hayes; Gregory T. Reeves The transcription factor NF-κB plays an important role in the immune system, apoptosis and inflammation. Dorsal, a Drosophila homolog of NF-κB, patterns the dorsal-ventral axis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 3032–3039.
Published: 15 August 2012
...Aharon Helman; Bomyi Lim; María José Andreu; Yoosik Kim; Tatyana Shestkin; Hang Lu; Gerardo Jiménez; Stanislav Y. Shvartsman; Ze’ev Paroush The dorsoventral (DV) axis of the Drosophila embryo is patterned by a nuclear gradient of the Rel family transcription factor, Dorsal (Dl), that activates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4409–4414.
Published: 15 November 2006
...Girish S. Ratnaparkhi; Songtao Jia; Albert J. Courey The Rel family transcription factor Dorsal patterns the dorsoventral axis of the Drosophila embryo by activating genes such as twist and snail and repressing genes such as decapentaplegic and zerknüllt . Dorsal represses transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (15): 3419–3429.
Published: 1 August 2005
...Atish Ganguly; Jin Jiang; Y. Tony Ip The maternal Toll signaling pathway sets up a nuclear gradient of the transcription factor Dorsal in the early Drosophila embryo. Dorsal activates twist and snail , and the Dorsal/Twist/Snail network activates and represses other zygotic genes to form...
Journal Articles
Journal: Development
Development (2004) 131 (10): 2387–2394.
Published: 15 May 2004
... when tested in vivo. In the present study, co-regulated neurogenic enhancers that are activated by intermediate levels of the Dorsal regulatory gradient are shown to contain several shared sequence motifs. These motifs permitted the identification of new neurogenic enhancers with high precision: five...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (24): 5635–5645.
Published: 15 December 2002
...Andy J. Chang; Donald Morisato Dorsoventral polarity of the Drosophila embryo requires maternal spätzle-Toll signaling to establish a nuclear gradient of Dorsal protein. The shape of this gradient is altered in embryos produced by females carrying dominant alleles of easter (ea D ) . The easter...
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (7): 1785–1793.
Published: 1 April 2002
...John Cowden; Michael Levine The maternal Dorsal nuclear gradient initiates the differentiation of the mesoderm, neurogenic ectoderm and dorsal ectoderm in the precellular Drosophila embryo. Each tissue is subsequently subdivided into multiple cell types during gastrulation. We have investigated...
Journal Articles
Journal: Development
Development (2001) 128 (23): 4729–4736.
Published: 1 December 2001
... Tube and protein kinase Pelle. Signaling through these components directs degradation of the IκB-like inhibitor Cactus and nuclear translocation of the Rel protein Dorsal. Here we show through confocal immunofluorescence microscopy that Pelle functions to downregulate the signal-dependent...
Journal Articles
Journal: Development
Development (2001) 128 (10): 1869–1879.
Published: 15 May 2001
...Rubén Darío Flores-Saaib; Songtao Jia; Albert J. Courey ABSTRACT In the Drosophila embryo, Dorsal, a maternally expressed Rel family transcription factor, regulates dorsoventral pattern formation by activating and repressing zygotically active fate-determining genes. Dorsal is distributed...
Journal Articles
Journal: Development
Development (2000) 127 (16): 3631–3644.
Published: 15 August 2000
... the dorsal ectoderm into two territories. Here, we present evidence that sog and dpp also play opposing roles during oogenesis in patterning the DV axis of the embryo. We show that maternally produced Dpp increases levels of the IkB-related protein Cactus and reduces the magnitude of the nuclear...
Journal Articles
Journal: Development
Development (1998) 125 (13): 2443–2450.
Published: 1 July 1998
... with a spatially restricted, extracellular ligand. Tube and Pelle then transduce the signal from activated Toll to a complex of Dorsal and Cactus. Here we demonstrate by an mRNA microinjection assay that targeting of either Tube or Pelle to the plasma membrane by myristylation is sufficient to activate the signal...
Journal Articles
Journal Articles
Journal: Development
Development (1997) 124 (19): 3855–3864.
Published: 1 October 1997
...David N. Edwards; Par Towb; Steven A. Wasserman ABSTRACT A signaling pathway active on the ventral side of the Drosophila embryo defines dorsoventral polarity. A cell surface signal relayed by Toll, Tube and Pelle releases the Rel-related protein Dorsal from its cytoplasmic inhibitor Cactus; free...
Journal Articles
Journal Articles
Journal: Development
Development (1993) 117 (1): 135–148.
Published: 1 January 1993
...Shubha Govind; Lynn Brennan; Ruth Steward ABSTRACT The maternal-effect gene dorsal encodes the ventral morphogen that is essential for elaboration of ventral and ventrolateral fates in the Drosophila embryo. Dorsal belongs to the rel family of transcription factors and controls asymmetric...
Journal Articles
Journal: Development
Development (1992) 116 (Supplement): 173–181.
Published: 1 April 1992
...Christine Thisse; Bernard Thisse ABSTRACT Maternal genes involved in dorsoventral (D/V) patterning of the Drosophila embryo interact to establish a stable nuclear concentration gradient of the Dorsal protein which acts as the morphogen along this axis. This protein belongs to the rel proto-oncogene...
Journal Articles
Journal: Development
Development (1992) 114 (1): 49–57.
Published: 1 January 1992
... of columnar epithelial cells derived from parasegment 2, is established by the positive action of the homeotic gene Sex combs reduced (Scr) . Embryos mutant for Scr lack a detectable placode, while ectopic Scr expression leads to the formation of ectopic salivary glands. In contrast, the dorsal-ventral extent...