...Nicoletta I. Petridou; Panayiota Stylianou; Paris A. Skourides FAK is a non-receptor tyrosine kinase involved in a wide variety of biological processes and crucial for embryonic development. In this manuscript, we report the generation of a new FAK dominant negative (FF), composed of the C terminus...

... of Derrière to induce dorsal or ventral mesoderm depends strictly on the location of expression and that a dominant-negative Derrière cleavage mutant completely blocks all mesoderm formation when ectopically expressed. This differs from the activity of similar Xnr2 cleavage mutant constructs, which...

... for correspondence (e-mail: [email protected] ) 3 March 1999 25 January 1999 © 1999 by Company of Biologists 1999 Xenopus TGF-β derrière Vg1 VegT Mesoderm Posterior Dominant negative Members of the TGFβ gene family are key regulators of mesoderm determination in Xenopus...

.... Additional signals from the organizer pattern the neural ectoderm along the antero-posterior axis. We devised highly specific methods utilizing constitutively active or dominant negative receptors to evaluate the role of retinoids in neural patterning. Microinjection of these reagents either augments...

...) in transgenic mice. This truncated FGF receptor is thought to act as a dominant negative protein by heterodimerization with endogenous FGF receptors. The presence of transgenic mRNA in the lens was confirmed by in situ hybridization and by polymerase chain reaction amplification of reverse transcribed lens RNA...

... for correspondence 23 05 1995 © 1995 by Company of Biologists 1995 Xenopus PDGF gastrulation dominant negative Gastrulation involves a complex, co-ordinated series of cell movements that give rise to the body plan in all vertebrates. In the frog, Xenopus laevis , this process...