... in the leading progenitor zone of the pLLP and restricted from the trailing zone through expression of the secreted Wnt inhibitors dkk1b and dkk2 . We have identified a zebrafish strain, krm1 nl10 , which carries a mutation in the kremen1 gene, a non-obligate co-receptor for the Dkk family of proteins. Previous...

...Christine Hassler; Cristina-Maria Cruciat; Ya-Lin Huang; Sei Kuriyama; Roberto Mayor; Christof Niehrs Kremen 1 and 2 (Krm1/2) are transmembrane receptors for Wnt antagonists of the Dickkopf (Dkk) family and function by inhibiting the Wnt co-receptors LRP5/6. Here we show that Krm2 functions...

...Corina Guder; Sonia Pinho; Tanju G. Nacak; Heiko A. Schmidt; Bert Hobmayer; Christof Niehrs; Thomas W. Holstein The dickkopf ( dkk ) gene family encodes secreted antagonists of Wnt signalling proteins, which have important functions in the control of cell fate, proliferation, and cell polarity...