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Keywords: differentiation
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Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (19): dev200986.
Published: 3 October 2022
... nephron progenitor exhaustion through their accelerated differentiation in pyrroline-5-carboxylate reductases 1 ( Pycr1 ) and 2 ( Pycr2 ) double-knockout kidneys. Pycr1 / Pycr2 -deficient progenitors showed normal cell survival, indicating no changes in cellular stress. Our results suggest that MAPK/ERK...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (17): dev200761.
Published: 8 September 2022
... differentiation. The heterozygous mutants were born with no pancreatic phenotype but displayed gradual acinar atrophy due to cell polarity defects in exocrine cells. Together, our findings imply a role for FAK in controlling the timing of pancreatic lineage commitment and/or differentiation in the embryonic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (15): dev200522.
Published: 29 July 2022
... in these precursors exhibit a delayed onset and reduced level of SMC differentiation and peristaltic activity, as well as dilatation of the ureter and renal pelvis (hydroureternephrosis) at birth and at postnatal stages. Molecular profiling revealed a delayed and reduced expression of the myogenic driver gene Myocd...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (12): dev200337.
Published: 27 June 2022
... found that one factor in the middle of the cascade, END-1, which straddles the distinct events of specification and differentiation, functions in both processes. Finally, we reveal roles for key GATA factors in establishing spatial regulatory state domains by repressing other fates, thereby defining...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (11): dev199660.
Published: 10 June 2022
... cells reveals that CDC25B indirectly increases the duration of the G1 phase, possibly by preventing phosphorylation of the retinoblastoma protein. Neural stem cells Neurogenesis Proliferation Differentiation Single-cell imaging Cell cycle kinetics G1 phase Retinoblastoma protein CDC25...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199840.
Published: 12 January 2022
...Matthew J. Shannon; Jennet Baltayeva; Barbara Castellana; Jasmin Wächter; Gina L. McNeill; Ji Soo Yoon; Jenna Treissman; Hoa T. Le; Pascal M. Lavoie; Alexander G. Beristain ABSTRACT In early placental development, progenitor cytotrophoblasts (CTB) differentiate along one of two cellular...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (1): dev199625.
Published: 4 January 2022
...Alicia McCarthy; Kahini Sarkar; Elliot T. Martin; Maitreyi Upadhyay; Seoyeon Jang; Nathan D. Williams; Paolo E. Forni; Michael Buszczak; Prashanth Rangan ABSTRACT Gamete formation from germline stem cells (GSCs) is essential for sexual reproduction. However, the regulation of GSC differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (14): dev199401.
Published: 26 July 2021
...Anna Kirillova; Lu Han; Honghai Liu; Bernhard Kühn ABSTRACT Terminally differentiated cells are generally thought to have arrived at their final form and function. Many terminally differentiated cell types are polyploid, i.e. they have multiple copies of the normally diploid genome. Mammalian heart...
Journal Articles
Journal: Development
Development (2021) 148 (12): dev199542.
Published: 28 June 2021
... differentiation, induced extensive transcriptional reprogramming in the colonic epithelium and enhanced Apc -initiated adenoma development. The Ets DNA-binding domain of EHF is therefore essential for postnatal homeostasis of the epidermis and colonic epithelium, and its loss promotes colonic tumour development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (12): dev188367.
Published: 25 June 2021
... , A. S. E. , Kumasaka , N. , Haldane , J. , Steer , J. , Patel , M. , Pearce , D. , Andersson , M. , Bonder , M. J. et al. ( 2021 ). Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation . Nat. Genet. 53 , 304 - 312 . 10.1038...
Journal Articles
Journal: Development
Development (2021) 148 (10): dev197475.
Published: 25 May 2021
.... Decline of GDNF levels in postnatal kidneys normalizes the ureteric bud and creates a permissive environment for continuation of the nephrogenic program, as demonstrated by morphologically and molecularly normal postnatal nephron progenitor self-renewal and differentiation. These results establish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev196329.
Published: 15 April 2021
.... Cells with substantively decreased H3K27 methylation differentiate into embryoid bodies, which contrasts with EZH2 null cells. PRC2 targets had varied requirements for H3K27me3, with a subset that maintained normal levels of repression in the absence of methylation. The primary cellular phenotype...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev197483.
Published: 15 April 2021
... pluripotent cranial neural crest cells and differentiate with distinct developmental timing and cellular morphologies. The mechanisms that divide neural crest cells into discrete populations are not fully understood. Here, we use single-cell RNA sequencing to transcriptomically define different populations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev197608.
Published: 15 February 2021
...Angel Stanoev; Christian Schröter; Aneta Koseska ABSTRACT During mammalian development and homeostasis, cells often transition from a multilineage primed state to one of several differentiated cell types that are marked by the expression of mutually exclusive genetic markers. These observations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev183442.
Published: 15 December 2020
... evident that nuclear pore complexes and their components also have multiple transport-independent functions. In recent years, an increasing number of studies have reported the involvement of nuclear pore complex components in embryogenesis, cell differentiation and tissue-specific processes. Here, we...
Journal Articles
Journal: Development
Development (2020) 147 (16): dev182725.
Published: 24 August 2020
... and discuss the possible functions of circRNAs in cell differentiation and development. References Aktaş , T. , Avşar Ilik , İ. , Maticzka , D. , Bhardwaj , V. , Pessoa Rodrigues , C. , Mittler , G. , Manke , T. , Backofen , R. and Akhtar , A. ( 2017 ). DHX9...
Journal Articles
Journal: Development
Development (2020) 147 (15): dev183384.
Published: 14 August 2020
...Lale Evsen; Xiaojun Li; Shuran Zhang; Sharjil Razin; Angelika Doetzlhofer ABSTRACT The evolutionarily conserved lethal-7 ( let-7 ) microRNAs (miRNAs) are well-known activators of proliferative quiescence and terminal differentiation. However, in the murine auditory organ, let-7g overexpression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev189712.
Published: 24 July 2020
...Mario Ledesma-Terrón; Nuria Peralta-Cañadas; David G. Míguez ABSTRACT Radial glial progenitors in the mammalian developing neocortex have been shown to follow a deterministic differentiation program restricted to an asymmetric-only mode of division. This feature seems incompatible with their well...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev178582.
Published: 22 June 2020
... and that, once specified, further mTEC development is NOTCH independent. In addition, we demonstrate that persistent NOTCH activity favors maintenance of undifferentiated TEPCs at the expense of cTEC differentiation. Finally, we uncover a cross-regulatory relationship between NOTCH and FOXN1, a master regulator...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev175596.
Published: 28 May 2020
... tissue morphology during embryonic development by governing key elements of cell shape, adhesion, migration and differentiation. * Authors for correspondence ( kenneth.yamada@nih.gov ; david.cruzwalma@nih.gov ) Competing interests The authors declare no competing or financial interests...