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Keywords: differentiation
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Journal Articles
Journal: Development
Development (2024) 151 (6): dev201621.
Published: 21 March 2024
... predominantly employ plastic culture wares, which offer a simplified representation of the in vivo microenvironment. Emerging evidence underscores the pivotal role of mechanical and topological cues in hPSC differentiation and maintenance. In this study, we cultured hPSCs on hydrogel substrates with spatially...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (21): dev201873.
Published: 3 November 2023
... of differentiation and integrate knowledge from cell atlases. We present ‘single-cell Type Order Parameters’ (scTOP): a statistical, physics-inspired approach for quantifying cell identity given a reference basis of cell types. scTOP can accurately classify cells, visualize developmental trajectories and assess...
Includes: Supplementary data
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Journal: Development
Development (2023) 150 (14): dev201386.
Published: 26 July 2023
... and transcriptomic approaches to study self-organization of human ESCs (hESC) in two-dimensional (2D) culture. Morphogen dynamics were controlled via optogenetic activation of canonical Wnt/β-catenin signaling (optoWnt), which drove broad transcriptional changes and mesendoderm differentiation at high efficiency...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (14): dev201045.
Published: 17 July 2023
... requires a careful balance between cellular proliferation and differentiation. Premature or delayed differentiation, for instance, can result in tissue imbalance, malformation or malfunction. Despite seemingly rigid constraints on development, however, there is flexibility in both the timing...
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Journal: Development
Development (2023) 150 (11): dev201280.
Published: 1 June 2023
... and transcriptional machinery of a cell to elicit qualitative transitions in its collective state. Single-cell RNA sequencing (scRNA-seq), which measures the distributions of possible transcriptional states in large populations of differentiating cells, provides an alternate view, in which development is marked...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (10): dev201411.
Published: 26 May 2023
... development in zebrafish and the mouse. Cilia Kidney Nephron Multiciliated cell Differentiation esrrγa ptgs1 Prostaglandin Zebrafish University of Notre Dame http://dx.doi.org/10.13039/100008109 Graduate Women in Science National Institutes of Health http...
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Journal: Development
Development (2023) 150 (10): dev201450.
Published: 22 May 2023
..., Manuela Scholze-Wittler for helping with the cell culture and providing the T BAC, Eun-ha Shin for helping with the establishment of differentiation protocol, and Elizabeth Robertson for sharing conditional Smad4 KO mice. Author contributions Conceptualization: B.G.H., F.K., P.T.; Methodology...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2023) 150 (6): dev201370.
Published: 16 March 2023
.... The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue...
Journal Articles
Journal: Development
Development (2023) 150 (5): dev201187.
Published: 7 March 2023
...Chunyang Ni; Michael Buszczak ABSTRACT Although differential transcription drives the development of multicellular organisms, the ultimate readout of a protein-coding gene is ribosome-dependent mRNA translation. Ribosomes were once thought of as uniform molecular machines, but emerging evidence...
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (22): dev201262.
Published: 16 November 2022
...Christina Geraldine Kantzer; Wei Yang; David Grommisch; Kim Vikhe Patil; Kylie Hin-Man Mak; Vera Shirokova; Maria Genander ABSTRACT The regulatory circuits that coordinate epidermal differentiation during development are still not fully understood. Here, we report that the transcriptional regulator...
Includes: Supplementary data
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Neural development
Journal: Development
Development (2022) 149 (21): dev200668.
Published: 31 October 2022
... a premature neuronal differentiation gene expression signature in ret wmr1/+ ENCCs. These results suggest that Ret signaling may regulate maintenance of a stem state in ENCCs. National Science Foundation http://dx.doi.org/10.13039/100000001 1942019 National Institutes of Health http...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (19): dev200986.
Published: 3 October 2022
... nephron progenitor exhaustion through their accelerated differentiation in pyrroline-5-carboxylate reductases 1 ( Pycr1 ) and 2 ( Pycr2 ) double-knockout kidneys. Pycr1 / Pycr2 -deficient progenitors showed normal cell survival, indicating no changes in cellular stress. Our results suggest that MAPK/ERK...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (17): dev200761.
Published: 8 September 2022
... differentiation. The heterozygous mutants were born with no pancreatic phenotype but displayed gradual acinar atrophy due to cell polarity defects in exocrine cells. Together, our findings imply a role for FAK in controlling the timing of pancreatic lineage commitment and/or differentiation in the embryonic...
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