... fashion. The ventral telencephalon acts as an instructive tissue, but the importance of the diencephalon in TCA mapping is unknown. We report that disruption of diencephalic development by Pax6 deletion results in a thalamocortical projection containing mapping errors. We used conditional mutagenesis...

... are partially co-expressed in the ventral diencephalon and the infundibulum; however, a functional requirement in murine pituitary development has not been reported. Here, we show by genetic lineage tracing that Tbx2 + cells constitute the precursor population of the neurohypophysis. However, Tbx2...

... regulating differentiation of GABAergic neuron subpopulations and suggest a role for Gata2 as a selector gene of both GABAergic neuron neurotransmitter and prosomere subtype identities in the developing diencephalon. Our results demonstrate for the first time that neuronal identities between distinct...

... of the midbrain floor. In FGFR mutants, the DA domain adopts characteristics that are typical for embryonic diencephalon, including the presence of Pou4f1 + cells among TH + cells, and downregulation of genes typical of midbrain DA precursors. Finally, analyses of chimeric embryos indicate that FGF signaling...

...Yongsu Jeong; Diane K. Dolson; Ronald R. Waclaw; Michael P. Matise; Lori Sussel; Kenneth Campbell; Klaus H. Kaestner; Douglas J. Epstein In caudal regions of the diencephalon, sonic hedgehog ( Shh ) is expressed in the ventral midline of prosomeres 1-3 (p1-p3), which underlie the pretectum...

... these activities. The mutant that lacked this enhancer demonstrated that Emx2 expression under the enhancer is solely responsible for diencephalon development. However, in telencephalon, the FB enhancer did not have activities in cortical hem or Cajal-Retzius cells, nor was its activity in the cortex graded. Emx2...

... are co-expressed in dopaminergic neurons, and combined overexpression of Sim1 and Otp leads to formation of supernumerary dopaminergic neurons in the ventral diencephalon. Arnt2, Sim1 and Otp thus are core components of a conserved transcriptional network, which specifies neuroendocrine as well as A11...

...Ayane Kataoka; Tomomi Shimogori The vertebrate thalamus contains multiple sensory nuclei and serves as a relay station to receive sensory information and project to corresponding cortical areas. During development, the progenitor region of the diencephalon is divided into three parts, p1, p2...

... Left-right asymmetry Pineal complex Diencephalon Epithalamus Zebrafish from beyond mutant In lizards and frogs, the pineal accessory organ (known as the parietal eye or frontal organ, respectively) is photoreceptive, expresses certain opsin family members and is thought to transmit...

...Alfonso Lavado; Oleg V. Lagutin; Guillermo Oliver The homeobox gene Six3 represses Wnt1 transcription. It is also required in the anterior neural plate for the development of the mammalian rostral forebrain. We have now determined that at the 15- to 17-somite stage, the prospective diencephalon...

... by transgenic and co-transfection experiments. These studies suggest that the seemingly continuous domains of Dlx gene expression in the telencephalon and diencephalon are in fact the combination of distinct cell populations within which different genetic regulatory interactions take place. * Author...

...Yung-Shu Kuan; Hung-Hsiang Yu; Cecilia B. Moens; Marnie E. Halpern The medial habenular nuclei of the zebrafish diencephalon, which lie bilateral to the pineal complex, exhibit left-right differences in their neuroanatomy, gene expression profiles and axonal projections to the unpaired midbrain...

... and eyes, the ventrally positioned hypothalamus, and the more caudally located diencephalon[from rostral to caudal: the prethalamus, the zona limitans intrathalamica(ZLI), the thalamus and the pretectum]. Although antagonizing Wnt proteins are known to establish the identity of the telencephalon and eyes...

... of Fez and Fezl is required for the formation of diencephalon subdivisions. The caudal forebrain can be divided into three transverse subdivisions: prethalamus (also called ventral thalamus), thalamus (dorsal thalamus) and pretectum. Fez;Fezl -deficient mice showed a complete loss of prethalamus...

... diencephalon, the optic and telencephalic vesicles. These defects are preceded by regionally decreased cell proliferation in the neuroepithelium, correlating with abnormally low D-cyclin gene expression. Increases in cell death also contribute to the morphological deficiencies at later stages. Molecular...

... Fasciculus retroflexus Interpeduncular nucleus Diencephalon A growing number of studies has dispelled the notion that lateralization of the brain is unique to the human cortex (see Rogers and Andrew, 2002 ). Even in the Drosophila brain, structural asymmetry has been linked to long-term memory...

... the dorsal diencephalon. These studies demonstrate that self-organizing signals from the basal plate regulate the formation of a potential patterning center in the ZLI in an orthogonal orientation in the alar plate, and thus create the potential for coordinated thalamic patterning in two dimensions. e...

... an important role in regulating the size of organizing centers. † Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 25 1 2005 ©2005. 2005 Barhl Apoptosis Shh Organizer Diencephalon The neuroectoderm emerges from...

..., a second conserved region that is inactive in the fish telencephalon is necessary for expression in the lateral pallium of mouse embryos. This regulatory region, which drives expression in the zebrafish diencephalon and hindbrain, is dependent on Pax6 activity and binds recombinant Pax6 in vitro. Thus...

... regions, and here we report similar findings for the developing forebrain. We show that Fgf8 and Fgf3 regulate different aspects of telencephalic development, and that Fgf3 alone is required for the expression of several telencephalic markers. Within the diencephalon, Fgf3 and Fgf8 act synergistically...