...G. Ian Gallicano; Christoph Bauer; Elaine Fuchs ABSTRACT Desmosomes mediate intercellular adhesion through desmosomal cadherins, which interface with plakoglobin (PG) and desmoplakin (DP) to associate with the intermediate filament (IF) cytoskeleton. Desmosomes first assemble in the E3.5 mouse...

...Jane E. Collins; Jo E. Lorimer; David R. Garrod; Sara C. Pidsley; Roger S. Buxton; Tom P. Fleming ABSTRACT The molecular mechanisms regulating the biogenesis of the first desmosomes to form during mouse embryogenesis have been studied. A sensitive modification of a reverse transcriptase - cDNA...

... of expression. In contrast to the progressive nature of tight junction formation, nascent desmosomes (formed from cavitation) appear mature in terms of their substructure and composition. The rapidity of desmosome assembly appears to be controlled by the time of expression of their transmembrane glycoprotein...

...Tom P. Fleming; David R. Garrod; Andrew J. Elsmore ABSTRACT The molecular processes underlying the formation of the first desmosomes in the mouse early embryo have been examined by immunocytochemical and biochemical techniques using antibody probes recognising desmosomal proteins 1 and 2 (dp1+2...