... response across species. Genetic deletion of IL6 in mice results in a 24 h delay in birth, which is restored to normal with administration of recombinant IL6 ( Robertson et al., 2010 ). In humans, IL8 is upregulated at parturition in the myometrium and the decidua, where it localizes to the stroma...

... GSE138375 for the MeDIP data; GSE98901 for RNA-seq data of developmental time course of decidualisation, E3.5 uteri and E11.5 decidua; and GSE138375 for RNA-seq data of uterine stromal cells. Funding This work was supported by the Biotechnology and Biological Sciences Research Council UK...

... in creating the intrauterine environment conducive to embryonic development. Among their many functions is the production of cytokines related to prolactin (PRL), including decidual prolactin-related protein (DPRP). DPRP is a heparin-binding cytokine, which is abundantly expressed in uterine decidua...

... of the decidualizing stroma. Message levels first increased in peripheral decidualizing cells, with the protein localizing close to the embryo during implantation (days 5.5-8.5). With the regression of the decidua beginning on day 9.5, a coordinated upregulation of both cathepsin B and cystatin C was observed implying...

... at the maternal-fetal interface is essential for early postimplantation development in mice. * Author for correspondence 03 06 1997 © 1997 by Company of Biologists 1997 adenosine deaminase 2′-deoxyadenosine adenosine decidua trophoblast cells placenta transgenic mice...

... cells, and found that it was expressed and activated during colonization of the maternal decidua. mRNAs for several other MMPs (stromelysin-1, stromelysin-3 and gelatinase A) and MMP inhibitors (TIMP-1 and TIMP-2) were expressed in the undifferentiated stroma toward the outside of the decidua, and TIMP...

...Swapan K. De; Michael T. McMaster; Sudhansu K. Dey; Glen K. Andrews ABSTRACT Oligodeoxyribonucleotide excess solution hybridization, Northern blot and in situ hybridization were used to analyze metallothionein gene expression in mouse decidua and placentae during gestation. Metallothionein (MT) -I...