... genes are components of morphogen signaling pathways, which control growth and patterning during development. Here we show that in Drosophila the Hox selector gene Ultrabithorax ( Ubx ) modulates morphogen signaling in the haltere through transcriptional regulation of the glypican dally. Ubx...

...) of Wg gradient formation is not fully understood. Here,we systematically analyzed the roles of glypicans Dally and Dally-like protein(Dlp), the Wg receptors Frizzled (Fz) and Fz2, and the Wg co-receptor Arrow(Arr) in Wg gradient formation in the wing disc. We demonstrate that both Dally and Dlp...

...Sabrina C. Desbordes; Bénédicte Sanson The Drosophila genes dally and dally-like encode glypicans, which are heparan sulphate proteoglycans anchored to the cell membrane by a glycosylphosphatidylinositol link. Genetic studies have implicated Dally and Dally-like in Wingless signalling in embryos...

... protein and Dpp signal transduction is potentiated by Dally, a cell-surface heparan sulfate proteoglycan, during assembly of several adult tissues. However, the molecular mechanism by which the Dpp morphogen gradient is established and maintained is poorly understood. We show evidence that Dally regulates...

... at the cell surface are integral membrane proteo-glycans. We show here that division abnormally delayed ( dally ), a Drosophila member of the glypican family of integral membrane proteoglycans is required for normal Dpp signaling during development, affecting cellular responses to this morphogen. Ectopic...

...Hiroshi Nakato; Tracy A. Futch; Scott B. Selleck ABSTRACT We have devised a genetic screen to obtain mutants affecting cell division patterning in the developing central nervous system of Drosophila . The division abnormally delayed (dally) locus was identified using a combination of “enhancer trap...