... arrested dauer state in response to environmental signaling. Dauer Diapause Hormone Decision daf-9 daf-12 National Institutes of Health http://dx.doi.org/10.13039/100000002 F31 NS120501-01 UF1-NS111697 California Institute of Technology http://dx.doi.org/10.13039...

... misexpression of lin-42 in the pre-dauer stage inhibits dauer formation, indicating that lin-42 acts as a negative regulator of this life history decision. These phenotypes place LIN-42 in opposition to the ligand-free form of the nuclear receptor DAF-12, which indirectly senses environmental conditions...

... subunit are required, probably in neurons, to trigger the action of DMPP. Using a forward genetic screen, we further demonstrated that the nuclear hormone receptor (NHR) DAF-12 is necessary to implement the developmental effects of DMPP. Therefore, a novel neuroendocrine pathway involving nAChRs...

... of the adult hermaphrodite. Although the level of daf-9 ::GFP expression in the head cells and spermatheca is constant,hypodermal daf-9 ::GFP expression is modulated by multiple inputs. In particular, daf-9 ::GFP expression in the hypodermis is absolutely dependent on daf-12 , the nuclear receptor...

... development, molting defects and increased adult longevity. The phenotype is sterol-dependent, and dependent on the activity of DAF-12, a nuclear hormone receptor. Genetic tests show that daf-9 is upstream of daf-12 in the genetic pathways for larval development and adult longevity. daf-9 encodes a cytochrome...