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Keywords: daf-12
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Journal Articles
Journal: Development
Development (2022) 149 (9): dev200173.
Published: 3 May 2022
... attributed. Summary: In animals such as Caenorhabditis elegans , a steroid hormone pathway controls both the entry and exit decisions into and out of the developmentally arrested dauer state in response to environmental signaling. Dauer Diapause Hormone Decision daf-9 daf-12...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3501–3511.
Published: 15 October 2010
... misexpression of lin-42 in the pre-dauer stage inhibits dauer formation, indicating that lin-42 acts as a negative regulator of this life history decision. These phenotypes place LIN-42 in opposition to the ligand-free form of the nuclear receptor DAF-12, which indirectly senses environmental conditions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (11): 2211–2222.
Published: 1 June 2006
... subunit are required, probably in neurons, to trigger the action of DMPP. Using a forward genetic screen, we further demonstrated that the nuclear hormone receptor (NHR) DAF-12 is necessary to implement the developmental effects of DMPP. Therefore, a novel neuroendocrine pathway involving nAChRs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (8): 1777–1786.
Published: 15 April 2004
... of the adult hermaphrodite. Although the level of daf-9 ::GFP expression in the head cells and spermatheca is constant,hypodermal daf-9 ::GFP expression is modulated by multiple inputs. In particular, daf-9 ::GFP expression in the hypodermis is absolutely dependent on daf-12 , the nuclear receptor...
Journal Articles
Journal: Development
Development (2002) 129 (1): 221–231.
Published: 1 January 2002
... development, molting defects and increased adult longevity. The phenotype is sterol-dependent, and dependent on the activity of DAF-12, a nuclear hormone receptor. Genetic tests show that daf-9 is upstream of daf-12 in the genetic pathways for larval development and adult longevity. daf-9 encodes a cytochrome...