...Bipin Kumar Tripathi; Kenneth D. Irvine ABSTRACT The protocadherins Fat and Dachsous regulate organ growth, shape, patterning, and planar cell polarity. Although Dachsous and Fat have been described as ligand and receptor, respectively, in a signal transduction pathway, there is also evidence...

.... Gradients across the tissue cause these bridges to be asymmetrically localised within each cell. Dachsous Fat Four-jointed Frizzled Starry-night Van Gogh ‘ Polarity is in my mind the essential problem. We have to explain why one part of a cell becomes different from another part...

... progenitor pool are regulated by Fat4-Dchs1 signaling between stromal cells and nephron progenitors, independently of YAP. Dachsous Fat Kidney Nephron Fig. 7. Potential mechanisms for influence of Fat4/Dchs1 signaling on nephrogenesis. Schematic of signaling between stromal cells...

...Mariana Rodrigues-Campos; Barry J. Thompson The atypical cadherins Dachsous (Ds) and Fat (Ft) are required to control the size and shape of tissues and organs in animals. In Drosophila , a key effector of Ds and Ft is the atypical myosin Dachs, which becomes planar polarised along the proximal...

...Praveer Sharma; Helen McNeill Fat (Ft) and Dachsous (Ds) are large cadherins that bind each other and have conserved roles in regulating planar cell polarity (PCP). We quantitatively analyzed Ft-Ds pathway mutant clones for their effects on ommatidial polarity in the Drosophila eye. Our findings...

... - 786 . Ambegaonkar A. A. , Pan G. , Mani M. , Feng Y. , Irvine K. D. ( 2012 ). Propagation of Dachsous-Fat planar cell polarity . Curr. Biol. 22 , 1302 - 1308 . Baena-López L. A. , Baonza A. , García-Bellido A. ( 2005 ). The orientation...

... domain of Ft can act independently of the Ft ICD in PCP and can trigger dominant-negative and boundary effects on Hippo activity, probably via binding to the protocadherin Dachsous. References Adler P. N. , Charlton J. , Liu J. ( 1998 ). Mutations in the cadherin superfamily...

... – the Dachsous (Ds) and Frizzled (Fz) systems – play key roles in the establishment and maintenance of such polarity. There has been great progress in uncovering the how these genes work together to produce planar polarity, yet fundamental questions remain unanswered. Here, we study the Drosophila larval ventral...

...Ada Repiso; Pedro Saavedra; José Casal; Peter A. Lawrence The larval ventral belts of Drosophila consist of six to seven rows of denticles that are oriented, some pointing forwards, some backwards. We present evidence that denticle orientation is determined almost entirely by Dachsous and Fat, one...

...José Casal; Peter A. Lawrence; Gary Struhl Planar polarity is a fundamental property of epithelia in animals and plants. In Drosophila it depends on at least two sets of genes: one set, the Ds system, encodes the cadherins Dachsous (Ds) and Fat (Ft), as well as the Golgi protein Four-jointed...

...Isabel Rodríguez The dachsous ( ds ) gene encodes a member of the cadherin family involved in the non-canonical Wnt signaling pathway that controls the establishment of planar cell polarity (PCP) in Drosophila . ds is the only known cadherin gene in Drosophila with a restricted spatial pattern...

...Paul N. Adler; Jeannette Charlton; Jingchun Liu ABSTRACT The adult cuticular wing of Drosophila is covered by an array of distally pointing hairs that reveals the planar polarity of the wing. We report here that mutations in dachsous disrupt this regular pattern, and do so by affecting frizzled...