...Yuji Hirao; John J. Eppig ABSTRACT Oocytes of almost all vertebrates become arrested at metaphase II to await fertilization. Arrest is achieved with the participation of a protein complex known as cytostatic factor (CSF) that stabilizes histone H1 kinase activity. MOS and mitogen-activated protein...

... presence of a cytostatic factor (CSF), requires a continuous supply of new short-lived proteins. Without this, the chromosomes decondense and the nuclear envelope reforms. Finally, we show that the entry into M-phase is accompanied by extensive protein phosphorylation, while the drug 6-dimethylami-nopurine...