... autonomous modes of organogenesis and homeostasis. We also attempt to interpret the results of previous in vivo studies of retinal development in light of the self-organising nature of the retina. Fig. 5. Self-sustaining system of intestinal crypt architecture and its stem cells. (A) Dynamic...

...Karl R. Fath; Steven D. Obenauf; David R. Burgess ABSTRACT We have explored the development of the brush border in adult chicken enterocytes by analyzing the cytoskeletal protein and mRNA levels as enterocytes arise from crypt stem cells and differentiate as they move toward the villus. At the base...

...Günter H. Schmidt; Douglas J. Winton; Bruce A. J. Ponder We have previously shown that the epithelium of each adult intestinal crypt in chimaeric mice is derived from a single progenitor cell. Whether the crypts are monoclonal from the outset - that is, are formed by the proliferation of a single...