...Francisca Nunes de Almeida; Rhian F. Walther; Mary T. Pressé; Evi Vlassaks; Franck Pichaud ABSTRACT Cdc42 regulates epithelial morphogenesis together with the Par complex (Baz/Par3-Par6-aPKC), Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these proteins work together and interact during...

... lacking Crb2a, a component of the Crumbs polarity complex, display compact wall integrity defects and fail to form trabeculae. Crb2a localization is very dynamic at a time when other cardiomyocyte junctional proteins also relocalize. Before the initiation of cardiomyocyte delamination to form...

... regulates wing growth by antagonizing the function of the transmembrane protein Crumbs (Crb). Ebi physically binds to the extracellular domain of Crb (Crb ext ), and this interaction is specifically mediated by WD40 repeats 7-8 of Ebi and a laminin G domain of Crb ext . Wing notching resulting from reduced...

...Kristin M. Sherrard; Richard G. Fehon The transmembrane protein Crumbs (Crb) functions in apical polarity and epithelial integrity. To better understand its role in epithelial morphogenesis, we examined Crb localization and dynamics in the late follicular epithelium of Drosophila . Crb...

.... , Skaer H. ( 2009 ). Crumbs stabilises epithelial polarity during tissue remodelling . J. Cell Sci. 122 , 2604 – 2612 . Chant J. , Herskowitz I. ( 1991 ). Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway . Cell...

...Clothilde Pénalva; Vincent Mirouse Patj is described as a core component of the Crumbs complex. Along with the other components, Crumbs and Stardust, Patj has been proposed as essential for epithelial polarity. However, no proper in vivo genetic analysis of Patj function has been performed in any...

...Emily C. N. Richardson; Franck Pichaud Crumbs (Crb) is a conserved apical polarity determinant required for zonula adherens specification and remodelling during Drosophila development. Interestingly, crb function in maintaining apicobasal polarity appears largely dispensable in primary epithelia...

... and forms ectopic folds rather than closing to make the neural tube. In contrast to zebrafish and Drosophila , in which orthologs of Epb4.1l5 control the apical localization and activity of Crumbs proteins, mouse Crumbs proteins are localized normally to the apical surface of the lulu mutant epiblast...

... of DE-cadherin, the intracellular domain of Crumbs, or by a dominant version of the monomeric GTPase Rho1 prevents localisation of the transmembrane protein IrreC-rst to the border between primary pigment cells and IOCs. As a consequence, the IOCs are not properly sorted and supernumerary cells survive...

... the apicalisation caused by aPKC . We conclude that an instrumental antagonistic interaction between aPKC and Lgl2 defines apicobasal polarity in early vertebrate development. 15 12 2004 ©2005. 2005 aPKC Crumbs Lgl Epithelial polarity Xenopus * Author for correspondence (e...

...Sang-Chul Nam; Kwang-Wook Choi Apicobasal cell polarity is crucial for morphogenesis of photoreceptor rhabdomeres and adherens junctions (AJs) in the Drosophila eye. Crumbs (Crb) is specifically localized to the apical membrane of photoreceptors, providing a positional cue for the organization...

.... In this process, dome controls the expression of the apical determinant Crumbs. In contrast to the ligand Upd, whose expression is limited to a pair of polar cells at both ends of the egg chamber, dome is expressed in all germline and follicle cells. However, the Dome protein is specifically localized...

... to the membrane at sites of cell adhesion, mediated by adherens junctions, initially spot and later belt-like, zonular structures, which encircle the apical side of the cell. Loss-offunction mutations in the Drosophila genes crumbs and stardust lead to the loss of cell polarity in most ectodermally derived...

...Elisabeth Knust; Ulrich Tepaß; Andreas Wodarz ABSTRACT Loss-of-function mutations in the Drosophila genes crumbs and stardust are embryonic lethal and cause a breakdown of ectodermally derived epithelia during organogenesis, leading to formation of irregular cell clusters and extensive cell death...