... of concomitant loss of both Cdx1 and Cdx2 . Here, we report that Cdx1-Cdx2 double mutants exhibit a severely truncated anteroposterior axis. In addition, these double mutants exhibit fused somites, a widened mediolateral axis and craniorachischisis, a severe form of neural tube defect in which early neurulation...

... vertebrate neurulation. * Author for correspondence (e-mail: [email protected] ) 22 8 2002 ©2002. 2002 Dishevelled Strabismus Planar cell polarity Convergent extension Neural tube defect Neurulation Midline Floorplate Craniorachischisis Looptail Xenopus...

...Teresa S. Musci; Richard J. Mullen Mouse embryos homozygous for the mutant gene Looptail (Lp) are characterized by craniorachischisis, an open neural tube extending from the midbrain to the tail. In the present study, experimental chimeric mice containing mixtures of genetically mutant (from Lp...