.../ Gastrulation Morphogenesis Convergent extension Zebrafish Nodal BMP National Institutes of Health https://dx.doi.org/10.13039/100000002 R00HD091386 Cancer Prevention and Research Institute of Texas https://dx.doi.org/10.13039/100004917 RP210227 Temporal dynamics of BMP/Nodal...

... et al., 2000 ; Ferrer-Vaquer et al., 2010 ). All animal studies in this work have been approved by the Pennsylvania State University Institutional Animal Care and Use Committee. In conclusion, our study reveals an important role of Tmem132a in the PCP pathway, convergent extension...

... signalling at later stages. Actomyosin cortex Tissue boundaries Planar polarity Drosophila Gastrulation Convergent extension Germband extension Parasegmental boundaries Live imaging Cell tracking MS2-MCP system LRR receptor University of Cambridge http://dx.doi.org/10.13039...

...-of-function experiments, we examine the roles of convergent extension and apical constriction, and define the role of the surface ectoderm during NTC. We show that NTC is a two-stage process with distinct spatiotemporal contributions of convergent extension and apical constriction at each stage. Convergent...

...Shiny Shengzhen Guo; Tiffany Y. K. Au; Sarah Wynn; Attila Aszodi; Danny Chan; Reinhard Fässler; Kathryn S. E. Cheah ABSTRACT The notochord drives longitudinal growth of the body axis by convergent extension, a highly conserved developmental process that depends on non-canonical Wnt/planar cell...

... by actomyosin-based oriented cell rearrangement and resulting dynamic tissue reshaping (convergent extension, CE). By labeling clusters of cells spanning the entire heart primordia, we show that the heart primordia converge toward the midline to form a narrow tube, while extending perpendicularly to rapidly...

... development Convergent extension Radial intercalation Live imaging Mouse National Institute on Deafness and Other Communication Disorders 10.13039/100000055 DC000059 The cellular mosaic that comprises the mammalian auditory sensory epithelium – the organ of Corti (OC...

... during convergent extension in the Drosophila embryo. These studies demonstrate that planar polarity is rapidly established in a spatiotemporally regulated pattern that is dynamically remodeled in response to changes in cell orientation. These findings reveal an unexpected plasticity that maintains...

... malformations – ‘neural tube defects’ – that result when closure fails. The process of neural tube closure is complex and involves cellular events such as convergent extension, apical constriction and interkinetic nuclear migration, as well as precise molecular control via the non-canonical Wnt/planar cell...

...Philipp Andre; Hai Song; Wantae Kim; Andreas Kispert; Yingzi Yang Mesoderm formation and subsequent anterior-posterior (A-P) axis elongation are fundamental aspects of gastrulation, which is initiated by formation of the primitive streak (PS). Convergent extension (CE) movements and epithelial...

..., cooperate to control PCP in the early mouse embryo. Two aspects of planar polarity can be analyzed quantitatively at cellular resolution in the mouse embryo: convergent extension of the axial midline; and posterior positioning of cilia on cells of the node. Analysis of the spatial distribution of brachyury...

... defects (VSDs) with ~15% penetrance; Fz2 +/− ;Fz7 −/− mice exhibit VSDs with ~50% penetrance and cleft palate with less than 10% penetrance; and Fz2 −/− ;Fz7 −/− mice exhibit convergent extension defects and mid-gestational lethality with 100% penetrance. When Fz2 and/or Fz7 mutations are combined...

...Masazumi Tada; Carl-Philipp Heisenberg Body axis elongation represents a common and fundamental morphogenetic process in development. A key mechanism triggering body axis elongation without additional growth is convergent extension (CE), whereby a tissue undergoes simultaneous narrowing...

... interaction with factors that determine its DNA target specificity. However, functional evidence linking TRIM28 to specific co-factors is scarce. chatwo , a hypomorphic allele of Trim28 , causes embryonic lethality and defects in convergent extension and morphogenesis of extra-embryonic tissues...

... RACK1 as a novel interaction partner of PTK7, a regulator of planar cell polarity that is necessary for neural tube closure. RACK1 is likewise required for Xenopus neural tube closure. Further, explant assays suggest that PTK7 and RACK1 are required for neural convergent extension. Mechanistically...

... the following morphogenetic mechanisms: (1) convergent extension in the neural plate (NP); (2) cell wedging along the anterior NP border; and (3) autonomous in-plane deformations outside the NP. Our numerical predictions agree relatively well with the observed morphology, as well as with our measured stress...

... in mesendoderm induction and gastrulation movements. Nodal activity is necessary for convergent extension in axial mesoderm and for head mesoderm migration. Using morpholino-mediated knockdown, we found that the Nodal ligands Xnr5 and Xnr6 are together required for mesendoderm induction, whereas Xnr1 and Xnr2...

... intercalation. Collectively, our data suggest that the distinct morphological features of the proliferative chondrocytes result from a convergent extension-like process that is regulated independently of chondrocyte maturation. * Author for correspondence( [email protected] ) 24 8 2009...

... regulated series of cell rearrangements that establishes the vertebrate body plan( Keller, 2002 ). A major driving force in vertebrate gastrulation is convergent extension (CE), a mechanism by which cells move towards the future dorsal side of the embryo and then intercalate between neighboring cells...

...Ming Shao; Zhong-Zhen Liu; Cheng-Dong Wang; Hong-Yan Li; Clémence Carron; Hong-Wei Zhang; De-Li Shi The Glypican family of heparan sulfate proteoglycans regulates Wnt signaling and convergent extension (CE) in vertebrate embryos. They are predicted to be glycosylphosphatidylinositol (GPI)-tethered...