...Isao Nagata; Norio Nakatsuji ABSTRACT Mouse cerebellar granule cells showed two types of migration behavior in microexplant cultures. They first migrated along their neurites, showing the typical contact guidance, and then oriented themselves at right angles to the parallel neurites, thus...

...P. Clark; P. Connolly; A. S. G. Curtis; J. A. T. Dow; C. D. W. Wilkinson ABSTRACT Electronics miniaturisation techniques have been used to fabricate substrata to study contact guidance of cells. Topographical guidance of three cell types (BHK, MDCK and chick embryo cerebral neurones) was examined...

..., and their close associations with similarly aligned extracellular matrix fibrils, suggest a process resembling contact guidance (Ebendal, 1977 ; LÖfberg et al . 1980; Fitzharris and Markwald, 1982 ; Nakatsuji et al . 1982 ; Newgreen, 1989). Contact guidance describes the tendency of cells to move...

... from the explant along radially oriented parallel bundles of their neurites, thus displaying typical contact guidance. Then, in almost all explants, they changed their orientation by 90° to extend cell processes and translocate perpendicular to the radial neurites. Orientation and migration of neurons...

... associations and a computer-based morphometric analysis of selected parameters within the migration substratum, relevant to this in vivo ‘contact guidance’ phenomenon. The study shows that a differentiated and aligned matrix of actinotrichial fibrils can be detected before invasion of the fin fold, at levels...

...P. Clark; P. Connolly; A. S. G. Curtis; J. A. T. Dow; C. D. W. Wilkinson ABSTRACT The photolithographic techniques of the microelectronics industry have allowed us to fabricate patterned plastic substrata to investigate contact guidance of animal tissue cells. The reactions of cells to single steps...

...Colin D. McCaig ABSTRACT Nerve orientation in response to electrical guidance cues in one direction and contact guidance cues in an orthogonal direction has been studied. Where neurites had a free choice between following contact guidance cues or electrical cues, the direction of nerve growth...