... with the nuclear localisation of YAP. To test this relationship, we developed several hydrogel-based approaches to alter blastomere geometry in cultured embryos. Unbiased clustering analyses of blastomeres from such embryos revealed that this relationship emerged during compaction. Our results therefore pinpoint...

.... This suggests that adhesion per se is not essential in the early cleavage stage embryos, that embryos develop normally if compaction does not occur until the morula stage, and that the zona pellucida suffices to maintain blastomere proximity. Although maternal E-cadherin is not essential for the completion...

... and E24-28 in human embryos, is crucial for the developing heart to maintain normal cardiac growth and function in response to an increasing hemodynamic load. Although, ventricular trabeculation and compaction are key morphogenetic events associated with this transition, the molecular and cellular...

... of extensive cell-cell contacts. * Present address: Max Plank Institute, Am Fassberg, PO Box 2841, D-37018 Göttingen, Germany † Author for correspondence 29 07 1994 © 1994 by Company of Biologists 1994 preimplantation mouse embryos compaction gp330 epithelium trophectoderm...

... are detectable in early and late 4-cell embryos, uvomorulin in 8-cell embryos is phosphorylated. 27 02 1992 © 1992 by Company of Biologists 1992 mouse uvomorulin compaction phosphorylation Fig. 4. [ 35 S]methionine incorporation into immunoprecipitates of embryos of various...

...David L. Becker; Catherine Leclerc-David; Anne Warner ABSTRACT In the mouse embryo, gap junctions first appear at the 8-cell stage as compaction is about to take place. Compaction of the embryo is important for the differentiation of the first two cell types; the inner cell mass...

... on the cytoskeletal or microvillous organization of unfertilized oocytes. Interphase cells from embryos prior to compaction showed limited disruption and loss of microvilli when exposed to PMA and foci of polymerized actin remained visible in the cytocortex of embryos up to the early 8-cell stage. When compacted late...

...) trypsin and 2% (w/v) EDTA (Gibco Ltd; Fleming, 1987 ). 02 03 1987 © 1987 by Company of Biologists 1987 mouse compaction division order lineage ICM cell division The mouse expanded blastocyst contains two distinct and committed cell subpopulations, the trophectoderm...

...Jeremy B. Levy; Martin H. Johnson; Harry Goodall; Bernard Maro’ ABSTRACT The effect of protein synthesis inhibitors on compaction of the 8-cell mouse embryo has been investigated. The effects observed depended upon the duration and time of drug application and on the features of compaction scored...

... by parallel but separate mechanisms. * C.N.R.S., Paris, France. 24 06 1985 Copyright © 1985 by Company of Biologists 1985 microtubules microfilaments mouse morula compaction polarization taxol nocodazole cytochalasin D The 8-cell stage of mouse embryogenesis...

...Roger K. W. Smith; Martin H. Johnson ABSTRACT The effects of aphidicolin, a reversible inhibitor of DNA polymerase alpha, both on replication and on development of the mouse embryo from the 2- and 4-cell stages to the compacted late 8-cell stage have been assessed. The continuous presence...