Skip Nav Destination
1-3 of 3
Smrita Chaudhury, Kazuhide S. Okuda, Katarzyna Koltowska, Anne K. Lagendijk, Scott Paterson, Gregory J. Baillie, Cas Simons, Kelly A. Smith, Benjamin M. Hogan, Neil I. Bower
Development (2020) 147 (18): dev190983.
Published: 18 September 2020
... that failed to be secreted in both mutants was a type II collagen (Col2a1). Col2a1 is normally secreted by notochord sheath cells, alongside which LECs migrate. col2a1a mutants displayed defects in the migratory behaviour of LECs and failed lymphangiogenesis. These studies thus identify Col2a1 as a key cargo...
Includes: Supplementary data
Development (2008) 135 (23): 3947–3958.
Published: 1 December 2008
... and shape to cartilage by controlling the timing of preceding and requisite molecular and histogenic events. In particular, we find that mesenchyme regulates FGF signaling and the expression of downstream effectors such as sox9 and col2a1 . The capacity of neural crest-derived mesenchyme to orchestrate...
Yi-Lin Yan, Craig T. Miller, Robert Nissen, Amy Singer, Dong Liu, Anette Kirn, Bruce Draper, John Willoughby, Paul A. Morcos, Adam Amsterdam, Bon-chu Chung, Monte Westerfield, Pascal Haffter, Nancy Hopkins, Charles Kimmel, John H. Postlethwait
Development (2002) 129 (21): 5065–5079.
Published: 1 November 2002
... of phenotype. RNase-protection assays showed that in morpholino-injected animals, the percent of splicing inhibition decreased from 80% at 28 hours post fertilization to 45% by 4 days. Homozygous mutant embryos had greatly reduced quantities of col2a1 message, the major collagen of cartilage. Analysis of dlx2...