... complex, and are dispensable for the maintenance of pluripotency. Sall4 NuRD ES cells Enhancer Transcription factor Co-repressor Embryonic stem cells (ESCs) have the potential to form any somatic cell type in the adult organism; that is, they are pluripotent. In order to properly...

...Priyanka Upadhyai; Gerard Campbell Transcriptional repressors function primarily by recruiting co-repressors, which are accessory proteins that antagonize transcription by modifying chromatin structure. Although a repressor could function by recruiting just a single co-repressor, many can recruit...

... levels by chromatin-modifying, co-repressor complexes provides transcriptional fine-tuning that drives development. The precise control of gene expression levels is known to be important for determining cell fate, and in many instances it is this variation in relative levels of transcripts...

... that encode proteins with structural relation to GRO/TUP1-like co-repressors. Using a yeast-based screen we found that STY interacts with several transcription factors, suggesting that STY, like GRO/TUP1, forms complexes in vivo. Proteins of the YABBY family, characterised by containing a partial HMG domain...

...J. Susie Zoltewicz; Nicola J. Stewart; Ricky Leung; Andrew S. Peterson Atrophins are evolutionarily conserved proteins that are thought to act as transcriptional co-repressors. Mammalian genomes contain two atrophin genes. Dominant polyglutamine-expanded alleles of atrophin 1 have been identified...

... and genetic analyses, we propose that SEUSS encodes a regulator of AGAMOUS and functions together with LEUNIG . Table 1. Table 2. *Author for correspondence (e-mail: [email protected] ) 12 10 2001 © 2002. 2002 LEUNIG AGAMOUS APETALA2 Co-repressor Flower...

...Yiorgos Apidianakis; Diane Grbavec; Stefano Stifani; Christos Delidakis Groucho (Gro) is the founding member of a family of transcriptional co-repressors that are recruited by a number of different transcription factors. Drosophila has a single gro gene, whose loss of function affects processes...

...Masatomo Kobayashi; Robert E. Goldstein; Miki Fujioka; Ze’ev Paroush; James B. Jaynes ABSTRACT Groucho acts as a co-repressor for several Drosophila DNA binding transcriptional repressors. Several of these proteins have been found to contain both Groucho-dependent and - independent repression...

... that is structurally most similar to FOG-1, but is expressed predominantly in heart and brain, as well as the ventral blood island and adult spleen. Ectopic expression and explant assays demonstrate that FOG proteins can act as repressors in vivo, in part through interaction with the transcriptional co-repressor, C...