... cleft palate by increased apoptosis . Differentiation 111 , 60 - 69 . 10.1016/j.diff.2019.10.001 Birnbaum , S. , Reutter , H. , Mende , M. , de Assis , N. A. , Diaz-Lacava , A. , Herms , S. , Scheer , M. , Lauster , C. , Braumann , B. , Schmidt , G...

...Hiroki Yoshioka; Akiko Suzuki; Chihiro Iwaya; Junichi Iwata ABSTRACT The etiology of cleft lip with or without cleft palate (CL/P), a common congenital birth defect, is complex, with genetic and epigenetic, as well as environmental, contributing factors. Recent studies suggest that fetal...

...Kendall J. Lough; Danielle C. Spitzer; Abby J. Bergman; Jessica J. Wu; Kevin M. Byrd; Scott E. Williams; Sally Dunwoodie; John Wallingford ABSTRACT Cleft palate (CP), one of the most common congenital conditions, arises from failures in secondary palatogenesis during embryonic development. Several...

... that mice lacking the epithelial-specific splicing factor Esrp1 have fully penetrant bilateral cleft lip and palate. In this study, we further investigated the mechanisms leading to cleft lip as well as cleft palate in both existing and new Esrp1 mutant mouse models. These studies included a detailed...

..., 19 genes had previously been associated with cleft palates. These included four distal-less homeobox (DLX) transcription factor-encoding genes, Dlx1 , Dlx2 , Dlx3 and Dlx5 and DLX target genes (including Barx1 , Gbx2 , Osr2 and Sim2). MOZ occupied the Dlx5 locus and was required for normal levels...

... surgically and require complex life-long treatments. Our studies utilized the well-characterized Pax9 −/− mouse model with a consistent cleft palate phenotype to test small-molecule Wnt agonist therapies. We show that the absence of Pax9 alters the expression of Wnt pathway genes including Dkk1 and Dkk2...

... of Biologists Ltd 2016 http://www.biologists.com/user-licence-1-1/ Highlighted article: Conditional Sox2 ablation affects dental epithelial stem cell proliferation and differentiation and causes arrested incisor development and abnormal molar development in rodents. Cleft palate Lef-1...

...Yu Lan; Nian Zhang; Han Liu; Jingyue Xu; Rulang Jiang Cleft palate is a common major birth defect for which currently known causes account for less than 30% of pathology in humans. In this study, we carried out mutagenesis screening in mice to identify new regulators of palatogenesis. Through...

... populating the craniofacial region, we studied two mouse models: Wnt1-Cre;Erk2 fl/fl and Osr2-Cre;Erk2 fl/fl . Wnt1-Cre;Erk2 fl/fl mice exhibited cleft palate, malformed tongue, micrognathia and mandibular asymmetry. Cleft palate in these mice was associated with delay/failure of palatal shelf elevation...

...Jing Zhou; Yang Gao; Yu Lan; Shihai Jia; Rulang Jiang Cleft palate is one of the most common birth defects in humans. Whereas gene knockout studies in mice have shown that both the Osr2 and Pax9 transcription factors are essential regulators of palatogenesis, little is known about the molecular...

...Yong-Ri Jin; Xiang Hua Han; Makoto M. Taketo; Jeong Kyo Yoon Outgrowth and fusion of the lateral and medial nasal processes and of the maxillary process of the first branchial arch are integral to lip and primary palate development. Wnt9b mutations are associated with cleft lip and cleft palate...

... of the oral cavity. The complexity of control of palatogenesis is reflected by the common occurrence of cleft palate in humans. Although the embryology of the palate has long been studied, the past decade has brought substantial new knowledge of the genetic control of secondary palate development. Here, we...

... the mouse white-spotting mutant belted (bt), whereas Adamts9 is essential for survival beyond 7.5 days gestation (E7.5). Functional overlap of Adamts9 with Adamts20 was identified using Adamts9 +/– ;bt/bt mice, which have a fully penetrant cleft palate. Palate closure was delayed, although eventually...

... to respiratory failure, with a suckling defect arising from a cleft palate. Our results demonstrate that Vlk is a novel vertebrate-specific PK that is involved in the regulation of the rate of protein export from the Golgi, thereby playing an important role in the formation of functional stroma by mesenchymal...

... ectodermal factor. Development 124 , 2235 -2244. Rice, R., Spencer-Dene, B., Connor, E. C., Gritli-Linde, A.,McMahon, A. P., Dickson, C., Thesleff, I. and Rice, D. P. (2004). Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J. Clin. Invest. 113 , 1692...

..., was also detected along the AP axis of the palate (Fig. 1D,H). The expression of Wnt5a and its receptors Fzd4 and Ror2 suggests a role for these genes in palatogenesis. The fact that Ror2 knockout mice exhibit a cleft palate phenotype(Schwabe et al., 2004) and that individuals with non...

... outgrowth. Extensive analyses of palatal gene expression in wild-type and Mn1 -/- mutant mice identified Tbx22 , the mouse homolog of the human X-linked cleft palate gene, as a putative downstream target of Mn1 transcriptional activation. Tbx22 exhibits a similar pattern of expression with that of Mn1 along...

...Stephen A. Murray; Kathleen F. Oram; Thomas Gridley Palate development requires precise regulation of gene expression changes,morphogenetic movements and alterations in cell physiology. Defects in any of these processes can result in cleft palate, a common human birth defect. The Snail gene family...

... 201203 28 7 2005 ©2005. 2005 Mouse Cleft palate Shox2 Epithelial-mesenchymal interaction The mammalian palate forms by the union of the primary palate and the two secondary palatal shelves. In mice, the development of the secondary palate initiates at embryonic day 11.5...

... humans. * Author for correspondence (e-mail: [email protected]) 16 6 2005 ©2005. 2005 Craniofacial Cleft palate Neural crest Holoprosencephaly Danio rerio Cranial neural crest (NC) cells in the vertebrate embryo form most of the cartilage and bones of the skull...