.... Deletion of a SOX17-binding cis- regulatory element in the TSS2 promoter impairs GB and EHBD development by reducing outgrowth of the nascent biliary bud. These findings reveal the existence of a SOX17-dependent autoregulatory loop that drives Sox17 expression above a critical threshold concentration...

... because the ancestral gene function was divided between them. In addition, novel functions may have evolved, owing to changes in cis-regulatory elements. Functional analysis of the PAX2/5/8 gene subfamily appears to support at least the first part of this hypothesis. The collective role of these genes has...

... 1993 © 1993 by Company of Biologists 1993 Drosophila lethal of scute gene cis -regulatory elements central nervous system neurogenesis Subdivision 1B of the X chromosome of Drosophila melanogaster contains at least six genetic functions involved in the development...

... by Company of Biologists 1991 bithorax complex Abdominal-B cis-regulatory elements infra-abdominal mutations The homeotic genes of Drosophila melanogaster act during development to specify the unique identities of each segmental unit (for review see Akam, 1987). The bithorax complex...

... 1990 © 1991 by Company of Biologists 1991 Drosophila development bithorax complex transcriptional regulation cis -regulatory elements Early in the development of Drosophila melanogaster , a number of maternal and zygotic genes divide the embryo into metameres and provide...