...Carlos Perez-Cervantes; Linsin A. Smith; Rangarajan D. Nadadur; Andrew E. O. Hughes; Sui Wang; Joseph C. Corbo; Constance Cepko; Nicolas Lonfat; Ivan P. Moskowitz ABSTRACT Identification of cell type-specific cis- regulatory elements (CREs) is crucial for understanding development and disease...

... their 7-stripe expression through stripe-specific cis-regulatory elements controlled by the preceding non-periodic maternal and gap gene patterns, whereas ‘secondary’ pair-rule genes are thought to rely on 7-stripe elements that read off the already periodic primary pair-rule patterns. Using a combination...

... was also observed in the forelimb( Fig. 2C ). Fig. 2. Comparative genomics reveals locations of candidate cis-regulatory elements. ( A ) Sequence comparison of mouse with human, opossum,chicken and zebrafish Tbx4 . Colored bars (top) denote location of cis-regulatory intervals; blue boxes...

... contains a cis-regulatory element that is responsible for its expression during oogenesis( Dorman et al., 2004 ; Ip et al., 1992 ; Sapir et al., 1998 ; Ward and Berg, 2005 ). This rho enhancer, termed Dmel rho 2.2 , is sufficient to drive the expression of a reporter gene in the developing follicle...

... gene, we have identified a wing-specific cis-regulatory element controlling the knot gene, which is expressed in the developing Drosophila wing but not the haltere. This regulatory element contains a single binding site that is crucial for activation by the transcription factor Cubitus interruptus (Ci...

.... Acad. Sci. USA 95 , 13483 -13488. * Author for correspondence (e-mail: arnosti@msu.edu ) 30 9 2003 © The Company of Biologists Limited 2003 2003 Enhancer Cis-regulatory element Enhanceosome Developmental programs of gene expression are controlled by `hard...

... developmentally regulated genes studied in this way (e.g., Jackson et al., 1989 ; Mueller and Wold, 1989 ). Similarly, in a cell facing another across a boundary, a cis -regulatory element might have a negative regulator bound to it, while the view from the opposing nucleus might reveal only positive...