... concentrated in the centric heterochromatin of mitotic cells in the early embryo and its interactions with heterochromatin protein 1 (HP-1) lead us to speculate that ORC may play some general role in chromosomal folding. To explore the role of ORC in chromosomal condensation, we have identified a mutant...

...Kunsoo Rhee; Debra J. Wolgemuth ABSTRACT The Aspergillus nimA gene encodes a Ser/Thr protein kinase which is required for mitosis, in addition to Cdc2, and which has been suggested to have a role in chromosomal condensation. In this study, we isolated a potential murine homologue of nimA, Nek2...

... formation and nuclear envelope breakdown, but not chromosome condensation. We also show that pelota , like roughex , affects patterning in the eye. Lastly, we have isolated genomic and cDNA clones for pelota and demonstrate that it encodes a protein with wide evolutionary conservation. All...

.... This suggests that the mechanism responsible for the developmental arrest of mature oocytes at metaphase II depends on cytoplasmic conditions that cause chromosome condensation to the metaphase state. In the case of the mouse, the metaphase II arrest must depend on the continuous synthesis of shortlived...

... effective concentrations of the protein synthesis inhibitor emetine, we further demonstrate that the appearance of this factor does not depend on newly made proteins, whereas the maintenance of metaphase-1 conditions and chromosome condensation activity (CCA), which has been related to the simultaneous...