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Keywords: chondrogenesis
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Journal Articles
Journal: Development
Development (2021) 148 (23): dev199607.
Published: 2 December 2021
... and Socs2 in PDGFRβ D849V cells suggests that overgrowth in mice involves PDGFRβ D849V activating the STAT5-IGF1 axis locally in the skeleton. Our study establishes that PDGFRβ D849V causes osteopenic skeletal phenotypes that are associated with intrinsic changes in SSCs, promoting chondrogenesis over...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199580.
Published: 24 September 2021
..., and identify key differences in the pathways that initiate formation of the hindlimb and forelimb. Using live image analysis of murine limb mesenchyme cells undergoing chondrogenesis in micromass culture, we distinguish a series of changes in cellular behaviours and cohesiveness that are required...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev173328.
Published: 28 May 2019
... on morphogen signaling. Specifically, two immature LMP populations with strong chondrogenic differentiation potential are identified. Cell sorting Chondrogenesis Mesenchymal progenitors Mouse limb bud Signaling Transcriptome The developing vertebrate limb bud is an excellent model...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev164459.
Published: 18 July 2018
... chromatin for gene activation remain unknown. Here, we address this knowledge gap using chondrogenesis as a model system. By profiling the whole transcriptome and the whole epigenome of wild-type and Sox9 -deficient mouse embryo limb buds, we uncover multiple structural and regulatory genes, including...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4510–4521.
Published: 15 December 2017
... of these lncRNAs, LOC102723505 , which we termed ROCR (regulator of chondrogenesis RNA), by RNA interference disrupted MSC chondrogenesis, concomitant with reduced cartilage-specific gene expression and incomplete matrix component production, indicating an important role in chondrocyte biology. Specifically, SOX9...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 601–611.
Published: 15 February 2017
... program that regulates the coordination of positional information and tissue differentiation in regenerating salamander limbs and tails . Regeneration Retinoic acid RAR Limb Patterning Chondrogenesis Urodele amphibians (salamanders) are capable of regenerating amputated limbs and tails...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 334–344.
Published: 15 January 2017
... of NPs, no other peptide hormones that affect remote organs have been identified from the heart. We identified osteocrin (Ostn) as an osteogenesis/chondrogenesis regulatory hormone secreted from CMs in zebrafish. ostn mutant larvae exhibit impaired membranous and chondral bone formation. The impaired...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4608–4619.
Published: 15 December 2016
.... 5 G-I,M), whereas the large majority of apoptotic cells in Prmt5 cKOs expressed low levels of SOX9 ( Fig. 5 J-N, Figs S4, S7 ). These cells did not express COL2, a marker of maturing chondrocytes, suggesting that these cells are in the early stages of chondrogenesis ( Fig. S8 ). The presence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 817–831.
Published: 1 March 2015
... chondrocytes. Here, we review how multiple signaling molecules, mechanical signals and morphological cell features are integrated to activate a set of key transcription factors that determine and regulate the genetic program that induces chondrogenesis and chondrocyte differentiation. Moreover, we describe...
Journal Articles
Journal: Development
Development (2014) 141 (20): 3848–3858.
Published: 15 October 2014
... of chondrogenesis via sclerotome specification. By contrast, treatment with TGFβ also supported chondrogenesis and stimulated Sox9 expression, but failed to induce the expression of Pax1 and Bapx1. On ectopic transplantation to immunocompromised mice, the cartilage particles developed under either condition became...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (20): 3978–3987.
Published: 15 October 2014
... that SHH-mediated induction of Nkx3.2 maintains the competence of somitic cells to initiate chondrogenesis in response to subsequent BMP signals by repressing BMP-dependent induction of GATA genes. Conversely, administration of BMP signals to PSM or forced expression of GATA family members in chick PSM...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 2085–2095.
Published: 15 May 2014
... of column formation (C,D). * Author for correspondence ( andrew.dudley@unmc.edu ) Competing interests The authors declare no competing financial interests. 29 10 2013 14 3 2014 © 2014. Published by The Company of Biologists Ltd 2014 Adhesion Chondrogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (4): 867–877.
Published: 15 February 2014
... interests The authors declare no competing financial interests. 18 1 2013 20 11 2013 © 2014. Published by The Company of Biologists Ltd 2014 Ezh2 Epigenetic regulation Neural crest Chondrogenesis Osteogenesis Mouse Neural crest cells (NCCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (17): 3791–3801.
Published: 1 September 2011
... ), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms. Chondrogenesis Indian hedgehog Gli...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1159–1167.
Published: 1 April 2010
... by the overexpression of Runx1 or Runx2 ( Fig. 5A ). Moreover, both proteins upregulated α 1(II) collagen expression, i.e. induced chondrogenesis ( Fig. 5A ). Surprisingly, ectopic expression of Runx1 or Runx2 in non-mesenchymal HeLa cells also induced Sox5 and Sox6 expression (data not shown...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (7): 1093–1104.
Published: 1 April 2009
... have determined the role of receptor Smads 1, 5 and 8 in chondrogenesis. Deletion of individual Smads results in viable and fertile mice. Combined loss of Smads 1, 5 and 8, however, results in severe chondrodysplasia. Smad1/5 CKO (cartilage-specific knockout)mutant mice are nearly identical to Smad1/5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (13): 2215–2220.
Published: 1 July 2008
..., together with impaired chondroitin sulfation and abnormal metabolism of the chondroitin sulfate proteoglycan aggrecan. Our findings identify JAWS as a key regulator of chondrogenesis and synovial joint positioning required for the restriction of joint formation to discrete stereotyped locations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 483–491.
Published: 1 February 2008
... FGF FGF receptor Apical ectodermal ridge (AER) Limb bud development Chondrogenesis The apical ectodermal ridge (AER) is a specialized ectodermal structure formed at the distal tip of the vertebrate limb bud that is essential for proximodistal (PD) patterning of the limb( Saunders, 1948...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3917–3928.
Published: 1 November 2007
...-depleted micromass culture cells under hypoxia provided further support for the regulatory role of HIF1αin chondrogenesis. Reduced expression of Sox9 , a key regulator of chondrocyte differentiation, followed by reduction of Sox6 , collagen type II and aggrecan in Hif1 α-depleted limbs raised...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (23): 4667–4678.
Published: 1 December 2006
...Byeong S. Yoon; Robert Pogue; Dmitri A. Ovchinnikov; Isaac Yoshii; Yuji Mishina; Richard R. Behringer; Karen M. Lyons Bone morphogenetic protein (BMP) signaling pathways are essential regulators of chondrogenesis. However, the roles of these pathways in vivo are not well understood. Limb-culture...