... Transdifferentiation Cell proliferation Sam68 the National Natural Science Foundation of China 32400696 the National Natural Science Foundation of China 32192400 Khdrbs1 drives redifferentiation of bipotential progenitor cell by inhibiting p53 in zebrafish biliarymediated liver...

..., tissue folding is a crucial process that relies on a combination of local and tissue-wide mechanical forces. Here, we investigate the contribution of cell proliferation to epithelial morphogenesis using the Drosophila leg tarsal folds as a model. We reveal that tissue-wide compression forces generated...

... is associated with the plasma membrane and plasmodesmata within the root apical meristem (RAM). Loss of ATM1 function results in decreased RAM size and reduced cell proliferation in a sugar-dependent manner. Auxin signaling and transcriptional responses were dampened in atm1-1 roots. Complementation of atm1-1...

... polarized cell shapes and oriented motility, with emigration from the thorax and subsequent dispersal to the abdomen and head. After the migration period, these cells adhered to each other, assembling into the AFB with a sheet-like architecture. Continuous cell proliferation occurred during and after...

... regulators. Alveolar development Transcriptional regulation Cell proliferation Lung mesenchyme Lipofibroblast Myofibroblast National Institutes of Health HL126703 UL1TR001442 HL086324 National Heart, Lung, and Blood Institute http://dx.doi.org/10.13039/100000050...

... Cell proliferation Angioblast differentiation cxcr4a cxcl12b Zebrafish National Natural Science Foundation of China http://dx.doi.org/10.13039/501100001809 32025014 National Key Research and Development Program of China 2018YFA0800200 2020YFA0804000 South...

... molecular, cellular, organ-level and organismal mechanisms. Sex difference Cell death Cell proliferation Stem cell Organ homeostasis Cell signaling Canadian Institutes for Health Research PJT-153072 GS4-171365 Natural Sciences and Engineering Research Council of Canada...

... development. Here, we show that Ror2-mediated non-canonical Wnt signaling in the dental mesenchyme plays a crucial role in cell proliferation, and thereby regulates root development size in mouse molars. Furthermore, Cdc42 acts as a potential downstream mediator of Ror2 signaling in root formation...

... with experimentally measured parameters to simulate embryonic tail bending. Actomyosin asymmetrically accumulated at the ventral side of the notochord, and cell proliferation of the dorsal tail epidermis was faster than that in the ventral counterpart during embryonic tail bending. Genetic disruption of actomyosin...

... regeneration and/or disease progression would provide valuable information on these processes. Here, we report a new genetic system that allows cell proliferation to be inhibited in a tissue-specific manner. We generated Cre- or Dre-inducible p21-GFP (ip21-GFP) transgenic mice that enable experimentally...

...Tünde Leviczky; Eszter Molnár; Csaba Papdi; Erika Őszi; Gábor V. Horváth; Csaba Vizler; Viktór Nagy; János Pauk; László Bögre; Zoltán Magyar ABSTRACT The E2F transcription factors and the RETINOBLASTOMA-RELATED repressor protein are principal regulators coordinating cell proliferation...

...., 2011 ). In mice, TLRs function in neural progenitor cells (NPCs) to regulate cell proliferation and neuronal versus glial (astrocyte) cell fate determination ( Lathia et al., 2008 ; Okun et al., 2010b ; Rolls et al., 2007 ; Shechter et al., 2008 ; Sloane et al., 2010 ). In the absence of TLR2...

..., and analyzed the biological activities of phosphomimetic (4E) and nonphosphorylatable (4A) mutants for those sites. In the neuroectoderm, the 4E but not the 4A mutant downregulated the Cdk inhibitor gene p27xic1 ( cdknx ) and posterior genes, and promoted cell proliferation, possibly forming a positive...

...)-mediated TE polarity in mammalian embryos. Mechanistically, CDX2 -depleted porcine embryos stalled at the blastocyst stage and exhibited apoptosis and inactive cell proliferation, possibly resulting from BMP4 downregulation. Moreover, TE cells in CDX2 -depleted blastocysts displayed defective F-actin...

... of GFP + cardiomyocyte contribution to the heart, amounting to at least 10% at one month of age ( Fig. 3 A, control group). This result does indeed indicate a more potent cell proliferation of p53 + lineage cardiomyocytes. Fig. 3. Activation of p53 + cardiomyocyte pool by injury...

... + channels establish a balance between cell proliferation and barrier properties in the neuroepithelium that lines the ventricles during development of the zebrafish brain ventricular system. Kcng4b Kcnb1 Neuroependyma extrusion Hydrocephalus Cell proliferation Tissue integrity Zebrafish...

...: Chemical treatments combined with live imaging reveal that re-epithelialization of zebrafish wounds utilizes TGFβ/integrin-dependent active keratinocyte crawling as well as epidermal rearrangements. FGF Re-epithelialization Skin TGF-β Wound healing Cell proliferation The epidermis, which...

...Carrie M. Spratford; Justin P. Kumar ABSTRACT During development, the rate of cell proliferation must be constantly monitored so that an individual tissue achieves its correct size. Mutations in genes that normally promote tissue growth often result in undersized, disorganized and non-functional...

... component of CLV3/CLE signaling in the RM. Mutations in PUB4 reduced the inhibitory effect of exogenous CLV3/CLE peptide on root cell proliferation and columella stem cell maintenance. Moreover, pub4 mutants grown without exogenous CLV3/CLE peptide exhibited characteristic phenotypes in the RM...

...Anneke Horstman; Hiroyuki Fukuoka; Jose M. Muino; Lisette Nitsch; Changhua Guo; Paul Passarinho; Gabino Sanchez-Perez; Richard Immink; Gerco Angenent; Kim Boutilier AINTEGUMENTA-LIKE (AIL) transcription factors are key regulators of cell proliferation and meristem identity. Although AIL functions...