... liver progenitors to functional hepatocytes requires anisotropic elongation of their nascent apical surfaces into tubular bile canaliculi. Bile canaliculi Cell differentiation Cell fate Cell polarity Liver development Rab35 Mouse European Molecular Biology Organization http...

... identity dynamics, including enhancer selection, cell fate induction, hierarchical differentiation through multipotent progenitor states and direct reprogramming by transcription factor overexpression. The model makes specific quantitative predictions, reproducing known reprogramming recipes...

... to reprogram somatic cells to induced pluripotent stem cells (iPSCs), mechanistic insights into the reprogramming process, and applications of iPSC technology in development and rejuvenation. Cell fate Epigenetics Induced pluripotent stem cells Reprogramming Small molecules Transcription factors...

... progression in rad21 mutants during early embryogenesis ( Fig. 2 ), strong transcriptional changes relate to the expression of cell cycle genes in this genotype. To assess how cohesin deficiency versus composition affects cell fate decisions in the tailbud, we used the bulk RNA-seq data to quantify...

... to tissue damage . Nature 550 , 475 - 480 . 10.1038/nature24271 Nuninger , C. , Papasaikas , P. , Ferralli , J. , Smallwood , S. and Tsiairis , C. D. ( 2024 ). Progressive cell fate specification in morphallactic regeneration ’. bioRxiv , 2024.02.08.579449...

... work is properly attributed. Summary: Pseudotime analyses of mouse embryonic stem cell-derived dorsal spinal interneurons identifies regulators and lineage relationships between different interneuron populations. Dorsal spinal cord Cell fate Stem cells Sensory interneurons Single-cell...

... and/or segregation of some essential fate determinants. Our RNA-seq and immunoblot analyses of Cep120 KO embryonic kidneys identified prominent changes in several components of Wnt signaling ( Fig. 4 ), several of which localize to centrosomes and have been shown to regulate cell fate ( Itoh et al., 2009 ; Zhang...

... for telencephalic development and that the interplay between Notch and miRNAs is essential for the control of neocortical progenitor behaviors and neuron cell fate decisions. * These authors contributed equally to this work ‡ These authors contributed equally to this work § Authors...

... in the adult mouse and human retina, including a conserved region nearby Prdm1 , a factor implicated in the specification of rod photoreceptors and suppression of bipolar cell fate. VSX2 interacts with the transcription factor OTX2 and can act to suppress OTX2-dependent enhancer transactivation of the Prdm1...

... pellucida, highlighting a potential risk of sexually transmitted infection in early pregnancy. Zika virus (ZIKV) Birth defects Miscarriage Developmental biology Cell fate Epidemic Michigan State University http://dx.doi.org/10.13039/100007709 National Institute of General...

... precursor pool. Sustained Wt1 expression in cardiomyocytes can change their cell fate into epicardial-like cells. wt1a wt1b Heart development Cardiomyocyte Epicardium Zebrafish Cell fate Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung http...

... Cell fate Cell plasticity Diabetes European Research Council http://dx.doi.org/10.13039/100010663 ERC-StG 715361 SPACEVAR Fonds de la Recherche Scientifique 34772792 – SCHISM Technische Universitat Dresden Deutsches Zentrum für Diabetesforschung...

... results from M cells prematurely adopting a head epidermis fate. This switch in fate normally takes place during pupal development after the eye has been patterned. Our results suggest that the timing of cell fate decisions is essential for correct eye development. * Author for correspondence...

... of the Wnt/β-catenin pathway, which is required for melanocyte development, induces activation of Mitf-M, in turn repressing FoxD3 expression. In conclusion, β-catenin overexpression promotes SCP cell fate decisions towards the melanocyte lineage. 29 6 2020 25 11 2021 © 2022. Published...

... interneuron formation. Cell fate microRNA Retina Neurogenesis National Institutes of Health R01EY024996 R21EY018707 Midwest Eye-Banks (Eversight) University of Michigan http://dx.doi.org/10.13039/100007270 Cellular diversity is a fundamental feature...

...Megan K. Rommelfanger; Adam L. MacLean ABSTRACT Cells do not make fate decisions independently. Arguably, every cell-fate decision occurs in response to environmental signals. In many cases, cell-cell communication alters the dynamics of the internal gene regulatory network of a cell to initiate...

...Lluc Mosteiro; Hanaa Hariri; Jelle van den Ameele ABSTRACT The intimate relationships between cell fate and metabolism have long been recognized, but a mechanistic understanding of how metabolic pathways are dynamically regulated during development and disease, how they interact with signalling...

...Natalie J. Milmoe; Abigail S. Tucker ABSTRACT Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This starts with the neural crest, which undergoes epithelial-to-mesenchymal transition (EMT) to form, amongst other tissues, many of the skeletal tissues...

... retina. This is achieved by the direct repressive action of Pou2f2 on the rod-inducing factor Nrl, providing a rare link between temporal identity factors and downstream regulators of cell fate choice in mammalian CNS development. Importantly, we provide evidence for cross-regulatory mechanisms operating...

... ascidian endoderm invagination, and shows that fate specification is in part uncoupled from the control of morphogenesis in early ascidian embryos. Nodal Ephrin Gastrulation Morphogenesis Cell fate Centre National de la Recherche Scientifique 10.13039/501100004794 ANR 2008 BLAN 0067...