... and eyes were reduced in size in mutants; however, overall body length and developmental timing were not affected. The craniofacial phenotype associates with decreased chondrocyte size and increased neural crest cell death. We found that autophagy is elevated in raptor mutants. Chemical inhibition...

... insight into how the current climate crisis affects insect reproduction. Drosophila Temperature Germline Stem cell Cell death Oogenesis National Institutes of Health R01 GM069875 R35 GM140857 R01 GM125121 Johns Hopkins University http://dx.doi.org/10.13039/100007880...

... molecular, cellular, organ-level and organismal mechanisms. Sex difference Cell death Cell proliferation Stem cell Organ homeostasis Cell signaling Canadian Institutes for Health Research PJT-153072 GS4-171365 Natural Sciences and Engineering Research Council of Canada...

... were caused by JNK-mediated cell death in the wing pouch via Eiger/TNF signaling. The JNK activation in M /+, yki /+ wing discs required the caspase Dronc, which is normally blocked by DIAP1. Notably, heterozygosity of yki reduced DIAP1 expression in the wing pouch, leading to elevation of Dronc...

...Piya Ghose; Shai Shaham ABSTRACT Cell death is an important facet of animal development. In some developing tissues, death is the ultimate fate of over 80% of generated cells. Although recent studies have delineated a bewildering number of cell death mechanisms, most have only been observed...

... induces signalling only in its cleaved form ( Gay and Gangloff, 2007 ). By contrast, both full-length and cleaved DNT1, DNT2 and mammalian NTs can induce signalling to elicit distinct functions, such as cell death versus cell survival, respectively ( Foldi et al., 2017 ; Lu et al., 2005...

... survival rate observed in SNCT rabbit embryos should be consistent with major differences between viable and non-viable specimens in quantitative parameters, including cell proliferation and cell death. Our observations suggest that inner cell death is the major issue. The higher cell death rate observed...

.... Ikaros Neurogenesis Medium spiny neurons Cell cycle Cell death Ikzf2 Ministerio de Economía y Competitividad 10.13039/501100003329 BFU2010-19630 SAF 2014-57160-R SAF2015-66505-R Instituto de Salud Carlos III 10.13039/501100004587 European Regional Development...

... within the maternally derived seed coat. In Arabidopsis , final seed size is determined by early expansion of the coenocytic endosperm, which then cellularises and subsequently undergoes developmental programmed cell death, breaking down as the embryo grows. Endosperm breakdown requires the endosperm...

.... Receptive synergid cell Pollen tube Cell death MADS box REM Fertilization Fundação para a Ciência e a Tecnologia 10.13039/501100001871 SFRH/BPD/99936/2014 Ministero dell'Istruzione, dell'Università e della Ricerca 10.13039/501100003407 MIUR-PRIN 2012 European...

...Amanda B. Wehner; Houari Abdesselem; Travis L. Dickendesher; Fumiyasu Imai; Yutaka Yoshida; Roman J. Giger; Brian A. Pierchala ABSTRACT During development of the peripheral nervous system, excess neurons are generated, most of which will be lost by programmed cell death due to a limited supply...

... mutant in which the jag1b gene is disrupted by an EGFP insertion. Loss of Jag1b causes cell death in the developing posterior crista and results in downregulation of fgf10a in the posterior prosensory cells. Inhibition of FGFR activity in wild-type embryos also causes loss of the posterior crista...

... to distinguish between these hypotheses, we have analysed whether ALE1 plays a role in regulating endosperm cell death, and investigated whether the cell death regulation and cuticle formation functions of ZOU can be separated during seed development. We have also studied the genetic relationship between...

... cells, and activates the JNK pathway. Overexpression of Draper or the JNK pathway in follicle cells is sufficient to induce death of the underlying germline, suggesting that there is coordination between the germline and follicular epithelium to promote germline cell death. Furthermore, activation...

... ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 2 11 2011 © 2012. Proliferation Caudal fin Cell death Gene network aldh1a2 ( raldh2 ) Zebrafish Fish and amphibians have the ability...

...Lukas Jakob Neukomm; Anne-Sophie Nicot; Jason Michael Kinchen; Johann Almendinger; Sérgio Morgado Pinto; Sheng Zeng; Kimon Doukoumetzidis; Hélène Tronchère; Bernard Payrastre; Jocelyn Franck Laporte; Michael Otmar Hengartner Multicellular organisms use programmed cell death to eliminate unwanted...

... control of neuronal numbers is achieved during neural development is largely unclear. Specifically, the role of programmed cell death in control of cell numbers has not been studied in the central brain neuroblast lineages. Here, we focus on four postembryonic neuroblast lineages in the central brain...

...Kathleen A. Galindo; Wan-Jin Lu; Jae H. Park; John M. Abrams Bcl-2 family members are pivotal regulators of programmed cell death (PCD). In mammals, pro-apoptotic Bcl-2 family members initiate early apoptotic signals by causing the release of cytochrome c from the mitochondria, a step necessary...

... wall patterning. This was further supported by our observations that the vessel elements of acl5 seemed to initiate the cell death program too early and that the xylem defects associated with acl5 could be largely phenocopied by induction of premature, diphtheria toxin-mediated cell death in the ACL5...

... 2 11 2006 © 2007. 2007 Drosophila Metamorphosis Histoblasts Morphogenesis Abdomen Cell death Cell replacement One of the main processes leading to the shaping of the three-dimensional body plan of higher organisms is the dynamic rearrangement of cell populations...