...Dayang Wu; Pei-Jiun Chen; Shu Chen; Yuanming Hu; Gabriel Nuñez; Ronald E. Ellis In the nematode Caenorhabditis elegans , CED-4 plays a central role in the regulation of programmed cell death. To identify proteins with essential or pleiotropic activities that might also regulate cell death, we used...

...Junying Yuan; H. Robert Horvitz ABSTRACT Mutations in the gene ced-4 block almost all of the programmed cell deaths that normally occur during Caenorhabditis elegans development. We have cloned the ced-4 gene using a ced-4 mutation caused by the insertion of the transposon Tc4. When microinjected...

..., the sisters of the NSM neurons, probably by regulating the cell death genes ced-3 and ced-4 . Techniques for culturing C. elegans are described by Brenner (1974) . All strains were grown at 20 °C unless otherwise indicated. The wild-type parent of all strains described here is C. elegans...