... the cell cycle of stem cells remain poorly understood. Here, we show that the Cdc25 homolog String (Stg) is a crucial regulator of germline stem cells (GSCs) and cyst stem cells (CySCs) in Drosophila testis. Through knockdown and overexpression experiments, we show that Stg is required for stem cell...

... of cdc2 (synonymous with cdk1 ) and of twine , the meiotic homolog of cdc25, which is required for Cdk1 activation. We found that Twine and Polo kinase levels are reduced in endos mutants, and identified Early girl (Elgi), a predicted E3 ubiquitin ligase, as a strong Endos-binding protein. In elgi mutant...

.... * Author for correspondence (e-mail: [email protected] ) 27 6 2005 ©2005. 2005 Myt1 Wee1 Cdk1 Cdc25 Meiosis Mitosis Spermatogenesis Oogenesis A conserved molecular mechanism that controls entry into mitosis in eukaryotic cells involves the activation...

... of oogenesis). Stage IV oocytes contain a store of inactive pre-MPF (Tyr15-phosphorylated Cdc2 bound to cyclin B2); the Cdc25 phosphatase that catalyzes Tyr15 dephosphorylation of Cdc2 is also present. However, the positive feedback loop that allows MPF autoamplification is not functional at this stage...

[email protected] ) 8 2 2002 © 2002. 2002 cki-1 CDC25 E lineage Endoderm Cell cycle C. elegans Cell proliferation is essential for many key processes that occur during development including organogenesis, tissue renewal and germline formation. ( Bartkova et al., 1997 ; Clurman...

... by allowing the repair of DNA before mitosis and the alignment of the chromosomes before the onset of anaphase. Fucoid zygote S/M checkpoint Aphidicolin Centrosomes CDK cdc25 Olomoucine © 2000 by Company of Biologists 2000 28 01 2000 21 03 2000 * Author...

... cdc25 homolog twine . Although meiosis is blocked in pelota and twine homozygotes, spermatid differentiation continues. pelota is also required for patterning in the eye and mitotic divisions in the ovary. We have cloned the pelota locus and show it encodes a 44×10 3 M r protein with yeast, plant, worm...

...Dineli Wickramasinghe; Sandy Becker; Mary K. Ernst; James L. Resnick; John M. Centanni; Lino Tessarollo; Laura B. Grabel; Peter J. Donovan ABSTRACT The cdc25 gene product is a tyrosine phosphatase that acts as an initiator of M-phase in eukaryotic cell cycles by activating p34 cdc2 . Here we...

...Bruce A. Edgar; Dara A. Lehman; Patrick H. O’Farrell ABSTRACT During postblastoderm embryogenesis in Drosophila , cell cycles progress in an invariant spatiotemporal pattern. Most of these cycles are differentially timed by bursts of transcription of string (cdc25) , a gene encoding a phosphatase...

...Catherine Courtot; Christian Fankhauser; Viesturs Simanis; Christian F. Lehner ABSTRACT We have identified a second cdc25 homolog in Drosophila . In contrast to string (the first homolog identified in Drosophila ) this second homolog, twine , does not function in the mitotic cell cycle...