... and then initiate leftward-directed heart tube elongation. Klf2 Wnt9 Cardiogenesis Zebrafish Morphogenesis Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 SE2016/7-3 OL 653/3-1 KR 3985/12-1 SE2016/13-1 SE2016/10-1 Fondation Leducq http://dx.doi.org...

...Rajani M. George; Beth A. Firulli; Ram Podicheti; Douglas B. Rusch; Brandon J. Mannion; Len A. Pennacchio; Marco Osterwalder; Anthony B. Firulli ABSTRACT The transcription factor HAND2 plays essential roles during cardiogenesis. Hand2 endocardial deletion ( H2CKO ) results in tricuspid atresia...

... transcription factors Cardiogenesis Epigenetic regulator Heart regeneration National Institutes of Health 10.13039/100000002 AR-067294 Fondation Leducq 10.13039/501100001674 Welch Foundation 10.13039/100000928 1-0025 Heart disease, the leading cause of death...

...Hinako Kidokoro; Sayuri Yonei-Tamura; Koji Tamura; Gary C. Schoenwolf; Yukio Saijoh ABSTRACT In the initiation of cardiogenesis, the heart primordia transform from bilateral flat sheets of mesoderm into an elongated midline tube. Here, we discover that this rapid architectural change is driven...

...Shaad M. Ahmad; Pritha Bhattacharyya; Neal Jeffries; Stephen S. Gisselbrecht; Alan M. Michelson Cardiogenesis involves the coordinated regulation of multiple biological processes by a finite set of transcription factors (TFs). Here, we show that the Forkhead TFs Checkpoint suppressor homologue...

... analysis on single cardiac lineage cells provides a high-resolution view of cardiac fate choice in the mouse embryo and during stem cell differentiation. Cardiac progenitor cells Cardiogenesis Embryonic stem cell Nkx2-5 Differentiation The heart is the first organ to form during mouse...

... contributed equally to this work Competing interests statements The authors declare no competing financial interests. 5 10 2011 © 2011. Cardiogenesis Flk1 (Kdr) Hemangioblasts Hematopoiesis VEGF Vasculogenesis Mouse Mesodermal cells give rise to blood...

...Aaron N. Johnson; Mayssa H. Mokalled; Tom N. Haden; Eric N. Olson Intercellular signal transduction pathways regulate the NK-2 family of transcription factors in a conserved gene regulatory network that directs cardiogenesis in both flies and mammals. The Drosophila NK-2 protein Tinman (Tin...

... cardiogenesis . Proc. Natl. Acad. Sci. USA 101 , 12573 - 12578 . Wheldon L. M. , Haines B. P. , Rajappa R. , Mason I. , Rigby P. W. , Heath J. K. ( 2010 ). Critical role of FLRT1 phosphorylation in the interdependent regulation of FLRT1 function and FGF receptor...

... level of regulation that could compensate for variations in interconnectivity among them ( Benazet et al., 2009 ). Our study on cardiogenesis, and that of Benazet et al. on limb patterning ( Benazet et al., 2009 ), suggests that the crossregulation between different signaling pathways is more robust...

... of California, San Diego, La Jolla, CA 92093, USA ‡ Present address: Department of Cardiology, Children's Hospital Boston, Harvard Medical School, 320 Longwood Avenue, Boston, MA 02115, USA Competing interests statement 6 4 2010 © 2010. Tbx20 Cardiogenesis Cardiac...

...,and for the origins of stem cells in the adult heart. * Author for correspondence (e-mail: [email protected] ) 24 2 2009 © 2009. 2009 Myelopoiesis Cardiogenesis GATA factors Second heart field Haemangioblasts Transcriptional regulation Evolution Adult stem cells Zebrafish...

... inductive signals Dpp and Wg. Genetic interactions show that tup cooperates with tin, pnr and Doc in heart cell specification. Germ layer-specific loss-of-function and rescue experiments reveal that Tup also functions in the ectoderm to regulate cardiogenesis and implicate the involvement of different LIM...

...Kai Jiao; Melissa Langworthy; Lorene Batts; Chris B. Brown; Harold L. Moses; H. Scott Baldwin The transforming growth factorβ (Tgfβ) signaling pathway plays crucial roles in many biological processes. To understand the role(s) of Tgfβ signaling during cardiogenesis in vivo and to overcome the early...

...., Charron, F.,Robitaille, L., Caron, S., Conner, D. A., Gessler, M., Nemer, M., Seidman, C. E. et al. ( 2001 ). A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106 , 709 -721. Burton, P. B., Raff, M. C., Kerr, P., Yacoub, M...

.... 2006 Fgf8 Anterior heart field Cardiogenesis Cell Survival Proliferation Pea3 Bmp4 Erk Mouse Myocardial progenitors are derived from early migratory mesoderm that forms bilateral heart fields. These populations organize and coalesce generating the heart field...

... the lethality of Hand mutants, and cardiac expression of a human HAND gene, or the caspase inhibitor P35,partially rescued the cardiac and lymph gland phenotypes. These findings demonstrate evolutionarily conserved functions of HAND transcription factors in Drosophila and mammalian cardiogenesis, and reveal...

... binding site E-box Cardiogenesis Mouse Anterior heart field Heart development is a precisely orchestrated process in which even subtle perturbations can have catastrophic consequences for the organism (reviewed by Fishman and Olson, 1997 ). During vertebrate embryogenesis, heart development...

... interaction between members of the T-box gene family. * Author for correspondence (e-mail: [email protected] ) 23 11 2004 ©2005. 2005 Tbx5 Tbx20 T-Box T-domain Cardiogenesis Cardiac Heart Development Xenopus laevis The vertebrate heart constitutes...

... 2004. 2004 Nkx2.5 BMP YY1 GATA SMADs Cardiogenesis Chick The heart is the first organ to develop during vertebrate embryogenesis and arises from cardiac progenitor cells that migrate into the anterior lateral mesoderm during gastrulation ( DeHaan,1965 ; Rawles,1943 ; Rosenquist...