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Keywords: cAMP
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Journal Articles
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Neural development
Journal: Development
Development (2022) 149 (17): dev200640.
Published: 5 September 2022
... to radially sort and myelinate peripheral axons. Elevation of cAMP, but not Rac1 activity, in csp −/− restores myelin ensheathment. Most importantly, we show a significant decrease in laminin expression within csp −/− posterior lateral line nerve and that forcing Laminin 2 expression in csp −/− fully restores...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev191874.
Published: 16 December 2020
... of the signalling pathways underlying the balance of GluR subtypes, we performed an RNA interference screen of candidate genes and found that postsynaptic-specific knockdown of dunce , which encodes cAMP phosphodiesterase, increased levels of GluR subtype A but decreased subtype B. Furthermore, bidirectional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 1926–1936.
Published: 1 June 2016
...Nancy Nader; Raphael Courjaret; Maya Dib; Rashmi P. Kulkarni; Khaled Machaca Vertebrate oocytes arrest at prophase of meiosis I as a result of high levels of cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) activity. In Xenopus , progesterone is believed to release meiotic arrest...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (20): 3537–3548.
Published: 15 October 2015
...% develop a prolapse of the hindgut by the late prism stage (∼8 h after C5a protein expression normally peaks). Since C5a orthologs efflux cyclic nucleotides, and cAMP-dependent protein kinase ( Sp -CAPK/PKA) is expressed in pigment cells, we examined whether C5a could be involved in gastrulation through...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (2): 343–351.
Published: 15 January 2015
... stage of meiotic prophase I. In the current study, we provide evidence that the level of cyclic AMP (cAMP) in oocytes regulates oocyte meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary. Our results show that the early meiotic development of oocytes is closely correlated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 85–94.
Published: 1 January 2012
... target gene expression was impaired, Smo-dependent activation of downstream components of the signaling pathway was increased in the absence of Gprk2. This suggests that Gprk2 does indeed play a role in terminating Smo signaling. However, loss of Gprk2 resulted in a decrease in cellular cAMP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (3): 421–430.
Published: 1 February 2011
...Leung Kim; Joseph Brzostowski; Amit Majithia; Nam-Sihk Lee; Vanessa McMains; Alan R. Kimmel In Dictyostelium , the interaction of secreted cAMP with specific cell surface receptors regulates the activation/de-activation of GSK3, which mediates developmental cell patterning. In addition...
Journal Articles
Journal: Development
Development (2009) 136 (11): 1869–1878.
Published: 1 June 2009
... signal from the somatic cells is cGMP. Using FRET-based cyclic nucleotide sensors in follicle-enclosed mouse oocytes, we find that cGMP passes through gap junctions into the oocyte,where it inhibits the hydrolysis of cAMP by the phosphodiesterase PDE3A. This inhibition maintains a high concentration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (18): 4555–4565.
Published: 15 September 2004
...-inducing action of DIF-1 but largely refractory to the repressive effect exerted by extracellular cAMP. During normal development, apically situated prestalk cells express the ecmB gene just as they commit themselves to stalk cell differentiation. In the Ax2/gskA– mutant, ecmB is expressed throughout...
Journal Articles
Journal: Development
Development (2004) 131 (7): 1597–1606.
Published: 1 April 2004
... of rickets , which encodes a G-protein coupled receptor in the glycoprotein hormone family that is a putative bursicon receptor. Furthermore, stimulation of components downstream of bursicon, such as a membrane permeant analog of cAMP, or ectopic expression of constitutively active forms of G proteins or PKA...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (3): 491–501.
Published: 1 February 2004
... active in GalT I-null sperm. Consistent with this, GalT I-null sperm have increased levels of cAMP that correlate closely with both the accelerated kinetics and co-factor-independence of GalT I-null sperm capacitation. By contrast, the kinetics of protein tyrosine phosphorylation and sperm motility...
Journal Articles
Journal: Development
Development (2003) 130 (17): 3977–3987.
Published: 1 September 2003
.... This pharmacological inhibition can be rescued by supplementing with protoporphyrin IX free acid,an activator of sGC, and membrane-permeant cGMP, indicating that NO/cGMP signalling is essential for MG neuron migration. Conversely, the stimulation of the cAMP/protein kinase A signalling cascade results in an inhibition...
Journal Articles
Journal: Development
Development (2002) 129 (18): 4315–4325.
Published: 15 September 2002
... cAMP Oocyte maturation Sea urchin Eggs of most animal species are fertilized by a single sperm and fusion of these two cells is essential for the activation of the developmental program of the zygote. Cases in which multiple sperm fertilize an egg, a condition known as polyspermy...
Journal Articles
Journal: Development
Development (1985) 89 (1): 367–382.
Published: 1 October 1985
... interaction, cell shape change, or some other event occurs which is necessary to trigger the chondrogenic differentiation of the cells (see Kosher, 1983a,b; Solursh, 1983 for reviews). The Key words: limb development, chondrogenesis, prostaglandins, cAMP, cartilage. 368 S. W. GAY AND R. A. KOSHER critical...