..., and ureteric bud ends were positioned abnormally, at a distance from the renal capsule. Analysis of genes important for ureteric bud morphogenesis revealed that the proto-oncogene c-ret was downregulated. Our results suggest that RARα and RARβ2 are required for generating stromal cell signals that maintain c...

...Pascale L. Durbec; Lena B. Larsson-Blomberg; Anita Schuchardt; Frank Costantini; Vassilis Pachnis ABSTRACT c-ret encodes a tyrosine kinase receptor that is necessary for normal development of the mammalian enteric nervous system. Germline mutations in c-ret lead to congenital megacolon in humans...

...Vassilis Pachnis; Baljinder Mankoo; Frank Costantini ABSTRACT The c-ret proto-oncogene encodes a receptor tyrosine kinase whose normal function has yet to be determined. To begin to investigate the potential role of this gene in vertebrate development, we have isolated cDNA clones representing...