... morpholino injection results in the loss of foxD3, snail2 and twist expression, whereas expression of c-myc, AP-2 and snail1 remains unaffected. Xphb2, its closest relative, cannot substitute for Xphb1, underlining the specificity of Xphb1 function. Epistatic analyses place Xphb1 downstream of c-myc...

...Chen He; Huiqing Hu; Rickmer Braren; Shun-Yin Fong; Andreas Trumpp; Timothy R. Carlson; Rong A. Wang The c-myc proto-oncogene, which is crucial for the progression of many human cancers, has been implicated in key cellular processes in diverse cell types, including endothelial cells that line...

...Nicole C. Dubois; Christelle Adolphe; Armin Ehninger; Rong A. Wang; Elisabeth J. Robertson; Andreas Trumpp The c-Myc protein has been implicated in playing a pivotal role in regulating the expression of a large number of genes involved in many aspects of cellular function. Consistent with this view...

...-catenin, the proto-oncogene c-myc ( Myc ), was increased in acinar cells lacking Apc, suggesting that c-myc expression is essential for hyperplasia. In support of this hypothesis, we found that conditional inactivation of c-myc in pancreata lacking Apc completely reversed the acinar hyperplasia. Apc loss...

... of Biologists 1994 lung development TGFβ N- myc c- myc mouse Lung development begins in mouse at 9.5 days post coitum (p.c.) as two endodermally derived epithelial buds from the primitive foregut grow into surrounding mesoderm (reviewed in Ten Have-Opbroek, 1991 ). The epithelium develops...

..., expression of the c- myc gene was enhanced and the transcription of PEC-specific genes ( MMP115, pP344 ) was completely repressed. However, transcription of lens-specific genes (α-, β γ- and -crystallin genes) remained silent in dedifferentiated pigment cells. Activation of lens- or PEC-specific genes...

...Laura L. Harris; John C. Talian; Peggy S. Zelenka ABSTRACT The present study uses the polymerase chain reaction and in situ hybridization to examine c- myc and N- myc mRNA in the embryonic chicken lens at 6,10,14 and 19 days of development and compares the pattern of expression obtained...

...Xavier Desbiens; Christophe Quéva; Thierry Jaffredo; Dominique Stéhelin; Bernard Vandenbunder ABSTRACT We have described the expression of three nuclear protooncogenes, c-myc, c-myb and c-ets-1 during feather morphogenesis in the chick embryo. In parallel with the expression patterns obtained...

... address: Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge MA 02138, USA. 20 07 1990 © 1990 by Company of Biologists 1990 oncogene neural crest somite neurogenesis c- myc N- myc The N- myc oncogene was discovered due...

... promoter coupled to a strong enhancer. Coinjection of the E1A gene failed to stimulate Ella activity further, perhaps because c-myc protein, which has been reported to transactivate this promoter, was already present at high levels in mouse oocytes. Activation of the Ella promoter in the absence of E1A...

...B. Vandenbunder; L. Pardanaud; T. Jaffredo; M. A. Mirabel; D. Stehelin ABSTRACT We have used in situ hybridization to study the spatial and temporal distribution of the transcription of three cellular oncogenes encoding DNA-binding proteins, c-ets 1, c-myb and c-myc during the development...

...Jacques Hourdry; Annie Brulfert; Michel Gusse; Damien Schoevaert; Michael V. Taylor; Marcel Mechali The expression of the proto-oncogene c-myc during oogenesis and embryonic development was followed by in situ hybridization using a cytological protocol adapted to amphibian embryos. The c-myc RNA...

...Sandra A. Rempel; Randal N. Johnston ABSTRACT Enhanced c-myc transcript abundance has been observed in a variety of human malignancies, in normal liver tissue induced to proliferate in vivo by partial hepatectomy and in cells in culture induced to proliferate with the addition of protein hormones...