... for spatiotemporal c-Src activity in sprouting angiogenesis in the retina, which is in contrast to the dominant focus on the role of c-Src in the maintenance of vascular integrity. Thus, mice specifically deficient in endothelial c-Src displayed significantly reduced blood vessel sprouting and loss in actin-rich...

... co-localizes with RhoB-or EEA1-positive endosomes and the non-receptor tyrosine kinase c-Src. We further demonstrate that Amotl2 interacts preferentially with and facilitates outward translocation of the phosphorylated c-Src, which may in turn regulate the membrane architecture. These data provide...

... Gene targeting Neural tube defect Hypocardiogenesis Cytoskeletal protein Attachment assay Focal adhesion plaque Cell migration Embryo fibroblast Focal adhesion kinase Paxillin pCAS 130 c-src Vinculin is a cytoskeletal protein of 117 kDa and is a major constituent of cell junctions...