... in Wg signaling have been suggested. Here, we describe a novel molecular mechanism by which Dpp signaling suppresses Wg outputs. Brinker (Brk), a transcriptional repressor that is downregulated by Dpp, directly represses naked cuticle ( nkd ), which encodes a feedback inhibitor of Wg signaling, in vitro...

..., optomotor-blind ( omb ) and brinker ( brk ),collaborate to initiate formation of the fifth longitudinal (L5) wing vein. omb is broadly expressed at the center of the wing disc in a pattern complementary to that of brk , which is expressed in the lateral regions of the disc and represses omb expression. We...