... require the regulation of kinesin and dynein by two adaptor proteins, Milton and Miro. Recently, we found that dynein heavy chain 64C (Dhc64C) is the primary motor protein for both anterograde and retrograde transport of mitochondria in the Drosophila bristle. In this study, we show that a molecular...

...Ranganayaki Nagaraj; Paul N. Adler The morphogenesis of Drosophila sensory bristles is dependent on the function of their actin and microtubule cytoskeleton. Actin filaments are important for bristle shape and elongation, while microtubules are thought to mediate protein and membrane trafficking...

...Mingyao Yang; Emma Hatton-Ellis; Pat Simpson Evolution of novel structures is often made possible by changes in the timing or spatial expression of genes regulating development. Macrochaetes, large sensory bristles arranged into species-specific stereotypical patterns, are an evolutionary novelty...

...Corinna Wülbeck; Pat Simpson ABSTRACT The stereotyped positioning of sensory bristles in Drosophila has been shown to result from complex spatiotemporal regulation of the proneural achaete-scute genes, that relies on an array of cis- regulatory elements and spatially restricted transcriptional...

...Pat Simpson; Roxane Woehl; Kazuya Usui The spatial distribution of sensory bristles on the notum of different species of Diptera is compared. Species displaying ancestral features have a simple organization of randomly distributed, but uniformly spaced, bristles, whereas species thought to be more...

...Julie Adam; Anna Myat; Isabelle Le Roux; Mark Eddison; Domingos Henrique; David Ish-Horowicz; Julian Lewis ABSTRACT The sensory patches in the vertebrate inner ear are similar in function to the mechanosensory bristles of a fly, and consist of a similar set of cell types. If they are truly...

... of the proteins of the EGR transcription factor family. As in the case of the most divergent member of the family, the Wilms’ tumor suppressor gene (WT-1), klu contains an additional zinc finger, which is only distantly related. Loss of klumpfuss function is semilethal and causes a variety of defects in bristles...

...LeeAnn Leshko-Lindsay; Victor G. Corces ABSTRACT Mutations in the furrowed (fw) gene of Drosophila result in defects in the development of the eye and mechanosensory bristles. The eyes are reduced in size, have furrows or crevices in the retina, and show a disturbed patterning of ommatidia...