... coordinately in regulating branching. Strikingly, branching morphogenesis in double knockouts is restored by Fgfr1 and Fgfr2 ( Fgfr1/2 ) knock-in alleles incapable of engaging canonical RTK signaling, suggesting that additional FGF-dependent mechanisms play a role in salivary gland branching. Fgfr1/2...

... between structure and function for exocrine gland end-pieces. Similar to bud formation, branching and the extent of branching morphogenesis is regulated by FGF10 signaling; depletion of FGF10 or receptors FGFR2 reduces branching in salivary glands ( Jaskoll et al., 2005 ; Ohuchi et al., 2000...

..., it identifies a mechanism involving RTK signaling and cell proliferative activity at the branch tip for branching morphogenesis that is apparently conserved across the animal kingdom. * Present address: School of Veterinary Medicine, Kitasato University, 35-1 Higashi23bancho, Towada, Aomori 034-0021...

... isolates and determined that Fgf9 expression parallels that of Wt1 , and similarly increases with gestational age in early lung development ( Fig. S3B ). Additionally, given the changes in branching morphogenesis in our Wt1 −/− lungs, we examined other specific hallmark genes of lung development...

...Adam Packard; William H. Klein; Frank Costantini ABSTRACT Ret signaling promotes branching morphogenesis during kidney development, but the underlying cellular mechanisms remain unclear. While Ret -expressing progenitor cells proliferate at the ureteric bud tips, some of these cells exit the tips...

..., the exact role of actomyosin contractility in force transmission and the related transcriptional changes during morphogenesis are not fully understood. Here, we report a mechanogenetic role of the actomyosin complex in branching morphogenesis using an organotypic culture system of mouse embryonic...

... of mammary epithelium. Our results demonstrate a pleiotropic role for FGF signaling in mammary fibroblasts, with implications for regulation of mammary stromal functions and epithelial branching morphogenesis. * Author for correspondence ( [email protected] ) Competing interests The authors...

... shuttling is largely dispensable in epithelial progenitors for both branching morphogenesis and sacculation. However, if maintained transcriptionally active in airways, nuclear Yap profoundly alters proximal-distal identity and halts epithelial differentiation. Taken together, these observations provide...

...://www.biologists.com/user-licence-1-1/ Summary: High-resolution analyses during ureteric bud branching reveal that HNFB1 is required for maintaining cell-cell contacts, for proper epithelial cell organization and for further differentiation of the collecting duct system. Kidney Branching morphogenesis...

...James G. Lefevre; Kieran M. Short; Timothy O. Lamberton; Odyssé Michos; Daniel Graf; Ian M. Smyth; Nicholas A. Hamilton Metanephric kidney development is orchestrated by the iterative branching morphogenesis of the ureteric bud. We describe an underlying patterning associated with the ramification...

... demonstrate that PTPRB negatively regulates branching morphogenesis in the mouse mammary epithelium. We show that Ptprb is highly expressed in adult mammary stem cells and also, although at lower levels, in oestrogen receptor-positive luminal cells. During mammary development, Ptprb expression...

...Elisabeth A. Rutledge; Jean-Denis Benazet; Andrew P. McMahon Branching morphogenesis creates arborized epithelial networks. In the mammalian kidney, an epithelial progenitor pool at ureteric branch tips (UBTs) creates the urine-transporting collecting system. Using region-specific mouse reporter...

.... References Affolter , M. and Caussinus , E. ( 2008 ). Tracheal branching morphogenesis in Drosophila: new insights into cell behaviour and organ architecture . Development   135 , 2055 - 2064 . 10.1242/dev.014498 Affolter , M. , Zeller , R. and Caussinus , E. ( 2009...

... gross defects in chorioallantoic branching morphogenesis and placental vascular patterning. Microangiography and 3D imaging revealed patchy perfusion of Egfl7 −/− placentas marked by impeded blood conductance through sites of narrowed vessels. Consistent with poor feto-placental perfusion, Egfl7...

...William P. Daley; Kazue Matsumoto; Andrew D. Doyle; Shaohe Wang; Brian J. DuChez; Kenn Holmbeck; Kenneth M. Yamada Branching morphogenesis of developing organs requires coordinated but poorly understood changes in epithelial cell-cell adhesion and cell motility. We report that Btbd7 is a crucial...

...Lemonia Chatzeli; Marcia Gaete; Abigail S. Tucker Salivary glands are formed by branching morphogenesis with epithelial progenitors forming a network of ducts and acini (secretory cells). During this process, epithelial progenitors specialise into distal (tips of the gland) and proximal (the stalk...

... is essential for efficient pre-mRNA splicing. Drosophila melanogaster Tracheal system Branching morphogenesis mRNA splicing Spliceosome Faint sausage Fandango Boehringer Ingelheim Fonds 10.13039/501100001645 Schweizerischer Nationalfonds zur Förderung der...

...Robert J. Huebner; Neil M. Neumann; Andrew J. Ewald Mammary branching morphogenesis is regulated by receptor tyrosine kinases (RTKs). We sought to determine how these RTK signals alter proliferation and migration to accomplish tube elongation in mouse. Both behaviors occur but it has been difficult...

... to quantify the regenerative potential of human mammary cells. Mammary stem cell Primary human mammary epithelial cells Basal Luminal Progenitor cells Branching morphogenesis Organoid Regenerative potential CD10 Terminal ductal-lobular units Collagen gel The mammary gland (MG) develops...

...Chong Pyo Choe; J. Gage Crump Branching morphogenesis depends on the precise temporal and spatial control of epithelial dynamics. In the vertebrate head, endodermal branches, called pharyngeal pouches, form through the transient stratification, collective migration and reorganization of epithelial...