... as permanent mutations in cellular genomes for extraction via single-cell transcriptomics. CRISPR Notch signaling Barcoding Brain development Brain scRNA-seq Neurogenesis National Science Foundation http://dx.doi.org/10.13039/100000001 DGE-2236662 National Institutes of Health...

... to peripheral input, highlighting neuron type-specific molecular differentiation programs in the developing thalamus. Brain development Neuronal identity Thalamus First-order nuclei Higher-order nuclei Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung http...

... disorders. With this view in mind, we consider the suitability of animal models for studying these diseases, highlighting human-specific features of human brain development. We conclude by proposing that one such feature, human-specific regulation of neurogenic time, might be key to understanding...

..., effects on neuronal migration were found to result directly from P19 secretion by neural progenitors triggering microglia accumulation within the P19 targeted area. Our findings highlight the crucial role of microglia during brain development and identify P19 as a previously unreported player in the neuro...

.... 2 2 2022 15 8 2022 © 2022. Published by The Company of Biologists Ltd 2022 Summary: A new technique combining Easi-CRISPR with in utero electroporation allows efficient and rapid visualization of endogenous proteins in embryonic brain tissue. CRISPR Brain development...

... of the brain. Apart from being highly specialized brain phagocytes, microglia modulate the development and functions of neurons and glial cells through both direct and indirect interactions. Thus, recognizing the elements that influence the homeostasis and heterogeneity of microglia in normal brain development...

... reduced neurogenesis. Our work provides the first link between a known function of Traip and proper brain development. We found that interphase nuclear localization is not required for Traip function, suggesting that Traip interphase functions are dispensable for MB-NB survival under normal...

...Jiancheng Liu; Xiwei Wu; Qiang Lu ABSTRACT During mammalian brain development, how different astrocytes are specified from progenitor cells is not well understood. In particular, whether astrocyte progenitor cells (APCs) start as a relatively homogenous population or whether there is early...

...Nereo Kalebic; Takashi Namba ABSTRACT Cell polarity is fundamentally important for understanding brain development. Here, we hypothesize that the inheritance and flexibility of cell polarity during neocortex development could be implicated in neocortical evolutionary expansion. Molecular...

.... Highlighted Article: This study describes a role of TCF7L2 in neuronal differentiation of thalamic glutamatergic neurons at two developmental stages, highlighting its involvement in the postnatal establishment of crucial thalamic electrophysiological features. TCF7L2 Thalamus Brain development...

.../ Highlighted Article: Using experiments and modeling, this study illustrates the importance of not only chemical morphogen gradients, but also mechanical stress distributions, in embryonic development of the cerebral hemispheres. Biomechanics Brain development Finite element model Growth law...

... of this strain demonstrates that p75 NTR regulates multiple aspects of brain development, including cortical progenitor cell survival, and that expression during early neurogenesis is required for appropriate formation of telencephalic structures. * These authors contributed equally to this work...

.... Collectively, our data provide the first evidence for involvement of Ccdc39 in hydrocephalus and suggest that the proper development of medial wall ependymal cilia is crucial for normal mouse brain development. * Authors for correspondence ( [email protected] ; [email protected] ) Competing...

... Neurogenesis Brain development Behavior Evolution Pleurodeles Notophthalmus Newt Vetenskapsrådet 10.13039/501100004359 Hjärnfonden 10.13039/501100003792 Cancerfonden 10.13039/501100002794 Wenner-Gren Foundation 10.13039/100001388 Karolinska...

...) lineage formation. We show that Barc is required for the generation of neurons during Drosophila brain development by ensuring correct neural progenitor proliferation and differentiation. Barc associates with components of the U2 small nuclear ribonucleoprotein (snRNP) complex, and its depletion causes...

...Mei Yang; Si-Lu Yang; Stephanie Herrlinger; Chen Liang; Monika Dzieciatkowska; Kirk C. Hansen; Ridham Desai; Andras Nagy; Lee Niswander; Eric G. Moss; Jian-Fu Chen Neural progenitor cells (NPCs) have distinct proliferation capacities at different stages of brain development. Lin28 is an RNA-binding...

[email protected] ) Competing interests The authors declare no competing financial interests. 27 2 2014 1 8 2014 © 2014. Published by The Company of Biologists Ltd 2014 Atomic force microscopy Elasticity Mechanical property Embryonic tissue Brain development Cerebral...

... approaches available to study brain development and evolution is impressive, but overall, the meeting identified our ignorance of human-specific traits. We must channel these diverse approaches to study human brain development and resolve fundamental questions related to human uniqueness. As Voltaire said...

... ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 23 4 2013 © 2013. Published by The Company of Biologists Ltd 2013 Lentiviral injection Brain development Gene expression Cre recombination...

... the developing vertebrate central nervous system. However, its conditional deletion at E12.5 in mouse causes few brain developmental problems, with the exception of the postnatal loss of the hippocampal radial glia stem cells and the dentate gyrus. We deleted Sox2 at E9.5 in the telencephalon, using a Bf1-Cre...