...Yasuhito Yahara; Tuyet Nguyen; Koji Ishikawa; Katsuhiko Kamei; Benjamin A. Alman ABSTRACT The mechanisms underlying bone development, repair and regeneration are reliant on the interplay and communication between osteoclasts and other surrounding cells. Osteoclasts are multinucleated monocyte...

... on allelic strength, developmental stage and cellular context. Bone development Diversity Retinoic acid Zebrafish Retinoic acid (RA) is the active metabolite of vitamin A (retinol) and has multiple roles during development (Rhinn and Dolle, 2012 ; Samarut et al., 2014). It is synthesized...

... signaling stimulates the expression and activity of Indian hedgehog, increases the expression of β-catenin and inhibits Notch2. Our findings identify Vegfa as a regulator of perichondrial vascularity and osteoblast differentiation at early stages of bone development. * Author for correspondence...

... in the mutant tissue. Bone development Hypertrophic chondrocyte Sox9 Terminal differentiation Transcription factor The terminal differentiation of hypertrophic chondrocytes is essential for endochondral ossification. During endochondral bone development, chondrocytes proliferate...

... Bone development cP4H Hypoxia Pdk1 ER stress Extracellular matrix Mouse Hypoxic conditions occur normally in various tissues during embryonic development, as well as postnatally (Dunwoodie, 2009 ; Maltepe and Simon, 1998 ; Mitchell and Yochim, 1968 ; Rodesch et al., 1992 ; Simon...

.... The zebrafish (Danio rerio) caudal fin has emerged as a model system for the study of bone development and regeneration. The fin comprises 16 to 18 bony rays, each containing multiple joints along its proximodistal axis that give rise to segments. Experimental observations on fin ray growth, regeneration...

... expression(Yun et al., 2002). * Author for correspondence (e-mail: [email protected]) 21 8 2007 © 2007. 2007 Hypoxia HIF1 HIF1α Mesenchymal condensation Chondrocyte differentiation Chondrogenesis SOX9 Joint formation Bone development VEGF GDF5 BMP SOX5 SOX6...

... with conditional disruption of β-catenin in the skeleton, but the phenotype is not identical to any one mouse model. This suggests that the role of IFT and cilia during endochondral bone development is not restricted to the known role for IFT in hedgehog signaling and may include a role for cilia or IFT...

... in developing cartilage. This similarity of cell death phenotypes and the deficient VEGFA production in Hif1a null epiphyseal chondrocytes demonstrate that HIF1α and VEGFA are components of a key pathway to support chondrocyte survival during embryonic bone development. * Author for correspondence (e...

... peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc. Natl. Acad. Sci. USA 95 , 13030 -13035. Coffin, J. D., Florkiewicz, R. Z., Neumann, J., Mort-Hopkins, T., Dorn II, G. W., Lightfoot, P., German, R., Howles, P. N., Kier...

... patterns suggest specific roles for TGF- β and c-fos in osseochondral development. 11 11 1987 © 1988 by Company of Biologists 1988 cartilage collagen growth factors growth plate proto-oncogenes bone development human mRNA The longitudinal growth of skeleton occurs mainly...