...Ilham Hogga; François Karch The Fab-7 chromatin domain boundary insures functional autonomy of the iab-6 and iab-7 cis -regulatory domains in the bithorax complex (BX-C). We have previously shown that chromatin insulators such as gypsy or scs min are potent insulators that cannot substitute...

... of abd-A resulted in a loss of heart-specific markers. We also demonstrate that abd-A and sevenup co-expression in cardial cells defined the location of ostia, or inflow tracts. Other genes of the Bithorax Complex do not appear to participate in heart specification,although high level expression...

...Stéphane Barges; Jozsef Mihaly; Mireille Galloni; Kirsten Hagstrom; Martin Müller; Greg Shanower; Paul Schedl; Henrik Gyurkovics; François Karch ABSTRACT The Drosophila bithorax complex Abdominal-B ( Abd-B ) gene specifies parasegmental identity at the posterior end of the fly. The specific pattern...

... in the T3 limb primordium. The regulation of one downstream target of UBX, the Distalless gene, provides a model for this transition at the molecular level. * Author for correspondence 30 05 1995 © 1995 by Company of Biologists 1995 Ultrabithorax Bithorax complex segment identity...

...Fernando Casares; Ernesto Sánchez-Herrero ABSTRACT The expression of the abdominal-A and Abdominal-B genes of the bithorax complex of Drosophila is controlled by cis -regulatory infraabdominal regions. The activation of these regions along the anteroposterior axis of the embryo determines where...

... for their segmental patterning functions. 25 07 1994 © 1994 by Company of Biologists 1994 bithorax Complex parasegment Ultrabithorax Distalless engrailed Drosophila The homeotic genes of Drosophila are responsible for diversifying the identities of each segment in both...

... of other cell types irreversibly (e.g. the spiracle primordia). We describe one cell type in the peripheral nervous system that makes sequential, independent responses to homeotic gene expression. We also provide evidence that supports the hypothesis of in vivo competition between the bithorax complex...

...Alan M. Michelson ABSTRACT Muscle diversification in the Drosophila embryo is manifest in a stereotyped array of myofibers that exhibit distinct segment-specific patterns. Here it is shown that the homeotic genes of the Bithorax complex control the identities of abdominal somatic muscles...

... of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032, USA * Author for correspondence 28 09 1992 © 1993 by Company of Biologists 1993 Drosophila development bithorax complex homeotic gene...

...Michele L. Lamka; Anne M. Boulet; Shigeru Sakonju ABSTRACT The Abdominal-B ( Abd-B ) gene, a member of the bithorax complex (BX-C), specifies the identities of parasegments (PS) 10-14 in Drosophila. Abd-B codes for two structurally related homeodomain proteins, ABD-B m and ABD-B r...

...Susan Cumberledge; Janos Szabad; Shigeru Sakonju The abdominal-A (abd-A) gene, a member of the bithorax complex, is required for the correct identity of parasegments (PS) 7 through 13. Mutations in iab-4, one of the crs-regulatory regions of abd-A , transform epidermal structures of PS 9 and also...

...Jeffrey Simon; Anne Chiang; Welcome Bender ABSTRACT Mutations in genes of the Polycomb (Pc) group cause abnormal segmental development due to ectopic expression of the homeotic products of the Antennapedia and bithorax complexes. Here the requirements for Pc group genes in controlling the abdA...

.... and Verma , I. M. ( 1987 ). Modification of fos proteins: phosphorylation of c-fos , but not v-fos , is stimulated by 12-tetradecanoyl-phorbol-13-acetate and serum . Molec. cell. Biol . 7 , 2201 – 2211 . Beachy , P. A. ( 1986 ). ‘The Ubx domain in the bithorax complex of Drosophila...

...Anne M. Boulet; Alan Lloyd; Shigeru Sakonju The Abdominal-B (Abd-B) gene, a member of the Drosophila bithorax complex, is required during development to specify the identity of parasegments 10– 14. Based on genetic studies, Casanova, J., Sánchez-Herrero, E. and Morata, G. (1986) Cell 47, 627-636...

... by Company of Biologists 1991 Drosophila development bithorax complex transcriptional regulation cis -regulatory elements Early in the development of Drosophila melanogaster , a number of maternal and zygotic genes divide the embryo into metameres and provide positional information...

...Ernesto Sánchez-Herrero The abdominal-A (abd-A) and Abdominal-B (Abd-B) genes of the bithorax complex (BX-C) specify the identity of most of the Drosophila abdomen. Six different classes of infraabdominal (iab) mutations within the BX-C transform a subset of the parasegments affected by the lack...

...Ana Macias; Jordi Casanova; Gines Morata We have developed a specific polyclonal antibody that recognizes the protein products of the abdominal-A (abdA) gene, a member of the bithorax complex of Drosophila . The normal expression domain extends from parasegments 7 to 13, in good correspondence...

...Jozsef Mihaly; Ilham Hogga; Janos Gausz; Henrik Gyurkovics; Frangois Karch Summary Parasegmental (PS)-specific expression of the homeotic genes of the bithorax-complex (BX-C) appears to depend upon the subdivision of the complex into a series of functionally independent cis-regulatory domains. Fab...

...Ana Busturia; Jordi Casanova; Ernesto Sánchez-Herrero; Rosa González; Ginés Morata ABSTRACT We report the embryonic and adult phenotypes of a number of mutations of the abd-A gene of the bithorax complex. Some of them result in loss of abd-A function in the whole abd-A domain and are usually lethal...

...Ernesto Sánchez-herrero; Michael Akam ABSTRACT The identities of the second through ninth abdominal segments of Drosophila are specified by two genes of the bithorax complex (BX-C), abdominal-A ( abd-A ) and Abdominal B ( Abd-B ). The correct deployment of these two genes requires an extensive...