...Tovah Nehrer; Tsvia Gildor; Majed Layous; Smadar Ben-Tabou de-Leon ABSTRACT The sea urchin skeletogenic gene regulatory network (GRN) shows high similarity to the GRN that controls vertebrate vascularization, suggesting that sea urchin biomineralization evolved through co-option of an ancestral...

... patterning of the sea urchin larval skeleton. PMCs Biomineralization Pattern formation Skeleton Wnt Sea urchin National Science Foundation http://dx.doi.org/10.13039/100000001 IOS 1656752 The movement of ions is responsible for regulating processes such as wound healing...

... in the formation of the skeleton in both processes. Echinoderm Biomineralization Regulatory networks Signalling Vegf References Adomako-Ankomah , A. and Ettensohn , C. A. (2013). Growth factor-mediated mesodermal cell guidance and skeletogenesis during sea urchin gastrulation...

... a large suite of effector genes that control the morphogenetic behaviors and biomineral-forming activities of skeletogenic cells. To better understand the gene regulatory control of skeletogenesis by Alx1, we used genome-wide ChIP-seq to identify Alx1-binding sites and direct gene targets. Our analysis...

... Hedgehog-responsive cells and is modulated by muscle loading. Biomineralization Fibrocartilage Indian hedgehog Lineage tracing Postnatal development Tendon enthesis Mouse The attachment sites of tendon to bone, termed entheses, are adapted to transfer muscle forces from tendon to bone...

... of biomineralization in metazoans. ‡ Author for correspondence ([email protected]) * These authors contributed equally to this work Competing interests The authors declare no competing financial interests. 31 10 2013 1 12 2013 © 2014. Published by The Company of Biologists Ltd...

... and controls downstream genes required for epithelial-mesenchymal transition and biomineralization. Expression of Alx1 is cell autonomous and regulated maternally through β-catenin and its downstream effector, Pmar1. Alx1 expression can be activated in other cell lineages at much later stages of development...

... enamel biomineralization. The present studies were designed to test the hypothesis that amelogenin as a supramolecular aggregate regulates crystal growth during enamel biomineralization. Antisense oligodeoxynucleotide strategy was used in a simple organ culture system to inhibit amelogenin translation...

... extracellular matrix. 13 06 1988 © 1988 by Company of Biologists 1988 in situ hybridization amelogenin gene epithelial differentiation extracellular matrix epithelial-mesenchymal interaction biomineralization Numerous approaches have been used to investigate and understand...

...Glenn L. Decker; William J. Lennarz 01 03 1988 © 1988 by Company of Biologists 1988 sea urchin spicule biomineralization skeleton glycoprotein cell ingression cell migration primary mesenchyme calcium m vitro Skeletogenesis, a key morphogenetic event...

...+ and associated glycoconjugates may be routed to this cavity via a secretory pathway. spicules biomineralization sea urchin development mesenchyme During gastrulation, the sea urchin embryo is actively involved in biomineralization. At this stage of development, the primary mesenchyme cells initiate...