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Keywords: basement membrane
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Journal: Development
Development (2023) 150 (17): dev201717.
Published: 11 September 2023
... the morphology of the adult organs. In the ovary, Chsy mutants exhibited altered stiffness of the basement membrane and muscle dysfunction, leading to a gradual degradation of the gross organ structure as mutant animals aged. Our observations show that normal CS function is required for the maintenance...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (6): dev201293.
Published: 20 March 2023
... conditional null mutants showed defective cell-cell and cell-matrix adhesion, both of which have been shown to play instructive roles in salivary gland branching. Loss of FGF signaling led to disordered cell-basement membrane interactions in vivo as well as in organ culture. This was partially restored upon...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2021) 148 (12): dev199281.
Published: 15 June 2021
...Johanna I. Englund; Alexandra Ritchie; Leander Blaas; Hanne Cojoc; Nalle Pentinmikko; Julia Döhla; Sharif Iqbal; Manuel Patarroyo; Pekka Katajisto ABSTRACT Epithelial attachment to the basement membrane (BM) is essential for mammary gland development, yet the exact roles of specific BM components...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2020) 147 (22): dev191726.
Published: 30 November 2020
... and lateral nasal processes. We demonstrate that Prickle1 , a key component of planar cell polarity signaling, is expressed in progenitors of the PTD and throughout tear duct morphogenesis. Disruption of Prickle1 stalls tear duct elongation; in particular, the loss of basement membrane deposition and aberrant...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2020) 147 (21): dev189183.
Published: 22 June 2020
... Wallingford ABSTRACT Laminin alpha 5 (LAMA5) is a member of a large family of proteins that trimerise and then polymerise to form a central component of all basement membranes. Consequently, the protein plays an instrumental role in shaping the normal development of the kidney, skin, neural tube, lung...
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Neural development
Journal: Development
Development (2020) 147 (9): dev182279.
Published: 1 May 2020
... differences between these two CNS regions with regard to how neurovascular barrier properties arise and are maintained. Table 2. Expression of major basement membrane receptors in the CNS neurovascular unit Table 1. Cellular sources of major vascular basement membrane molecules...
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181420.
Published: 21 February 2020
... in the developing optic cup require neural crest. Ultrastructural analysis reveals that basement membrane formation around the developing eye is also dependent on neural crest, but only specifically around the retinal pigment epithelium. Neural crest cells produce the extracellular matrix protein nidogen: impairing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (12): dev159657.
Published: 11 June 2018
...-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome . Development   136 , 3495 - 3504 . 10.1242/dev.036087 Bartel , D. P. ( 2009 ). MicroRNAs: target recognition and regulatory functions . Cell   136 , 215 - 233 . 10.1016/j.cell.2009.01.002...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4350–4362.
Published: 1 December 2017
...Julien Chlasta; Pascale Milani; Gaël Runel; Jean-Luc Duteyrat; Leticia Arias; Laurie-Anne Lamiré; Arezki Boudaoud; Muriel Grammont The regulation of morphogenesis by the basement membrane (BM) may rely on changes in its mechanical properties. To test this, we developed an atomic force microscopy...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1165–1176.
Published: 1 April 2017
... depends on epidermal cellular protrusions that directly contact pObs only where an otherwise occluding basement membrane remains incompletely assembled. Progressively separated pObs pools then continue regenerating independently to collectively re-form a now branched skeletal structure. * Authors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3933–3943.
Published: 1 November 2016
... development, yet the underlying mechanism has remained elusive. We show that a unique composition of blood vessels facilitates the role of the endothelium in bone mineralization and morphogenesis. Immunostaining and electron microscopy showed that the endothelium in developing bones lacks basement membrane...
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Journal Articles
Journal: Development
Development (2012) 139 (2): 411–422.
Published: 15 January 2012
...William P. Daley; Elise M. Gervais; Samuel W. Centanni; Kathryn M. Gulfo; Deirdre A. Nelson; Melinda Larsen The basement membrane is crucial for epithelial tissue organization and function. However, the mechanisms by which basement membrane is restricted to the basal periphery of epithelial tissues...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4535–4544.
Published: 15 October 2011
... 12.5 kidneys revealed an almost complete absence of basement membrane proteins and reduced levels of α6 integrin and FGF2. mRNA levels for fibroblast growth factor 2 (FGF2) and mediators of the GDNF/RET and WNT11 signaling pathway were also decreased. Furthermore, collecting duct cells derived from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1297–1308.
Published: 1 April 2011
... in the fully delaminated epicardium. The present gene-targeting experiments demonstrate that mouse embryos lacking Flrt2 expression arrest at mid-gestation owing to cardiac insufficiency. The defects in integrity of the epicardial sheet and disturbed organization of the underlying basement membrane closely...
Includes: Supplementary data