...Muriel Desbois; Brock Grill ABSTRACT Spatially and temporally accurate termination of axon outgrowth, a process called axon termination, is required for efficient, precise nervous system construction and wiring. The mechanosensory neurons that sense low-threshold mechanical stimulation or gentle...

...Tessa Sherry; Ava Handley; Hannah R. Nicholas; Roger Pocock ABSTRACT Brain development requires precise regulation of axon outgrowth, guidance and termination by multiple signaling and adhesion molecules. How the expression of these neurodevelopmental regulators is transcriptionally controlled...

... interneurons. In the differentiation of V2a and V2b cells, Notch signaling promotes V2b fate at the expense of V2a fate. Later, V2b cells extend axons along the ipsilateral side of the spinal cord and express the inhibitory transmitter GABA. Notch signaling has been reported to inhibit the axonal outgrowth...

.... , Kamiguchi , H. , Fukuda , M. and Hisanaga , S.-i. ( 2012 ). LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner . J. Neurosci. 32 , 6587 - 6599 . 10.1523/JNEUROSCI.5317-11.2012 Takefuji , M. , Mori , K. , Morita , Y...

... the diverse activities of the BMPs. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 17 10 2012 © 2013. Published by The Company of Biologists Ltd Axon guidance Axon outgrowth Bone...

... subpopulations have stereotypic cell body positions and show specific spatial axon trajectories. Our knowledge of MN axon outgrowth remains incomplete. Here, we report a zebrafish gene-trap mutant, short lightning ( slg ), in which prdm14 expression is disrupted. slg mutant embryos show shortened axons in caudal...

.... 18 4 2012 © 2012. Neuromuscular junction β-Catenin AChR Axon outgrowth Retrograde signals Mouse The neuromuscular junction (NMJ), a synapse between motoneurons and muscle fibers, is crucial for control of muscle contraction. This classic chemical synapse has...

... in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms. FOXO PTEN Axon outgrowth Dendrite morphology Neurodevelopment The phosphatidylinositol 3-kinase (PI3K...

[email protected] ) * Present address: Fred Hutchinson Cancer Research Center, Seattle, WA 98109,USA ‡ Present address: HHMI Janelia Farm Research Campus, Ashburn, VA 20147,USA 27 7 2009 © 2009. © 2009. 2009 Drosophila Metamorphosis Ecdysone EcR Axon outgrowth...

... 2009. 2009 UNC-40 UNC-73 WAVE Dcc Trio GEX-2 GEX-3 UNC-95 Muscle arms Axon outgrowth Caenorhabditis elegans The postsynaptic membrane is not a passive partner in the development of the neuromuscular junction (NMJ). For example, the striated muscles...

..., 10900 Euclid Avenue, Cleveland, Ohio 44106,USA † These authors contributed equally to this work 11 8 2004 © 2004. 2004 Drosophila melanogaster Neuronal fate specification Motoneurons Interneurons Axon outgrowth Nkx6 hb9 (exex) lim3 islet eve vnd...

... outgrowth, demonstrating that Brn3c could promote axon outgrowth in the absence of Brn3b. Our results reveal a complex genetic relationship between Brn3b and Brn3c in regulating the retinal ganglion cell axon outgrowth. References Bowers, W. J., Howard, D. F. and Federoff, H. J. ( 2000 ). Discordance...

... (e-mail: [email protected] ) * Current address: Institute of Neuroscience, University of Oregon, Eugene OR 97403, USA 02 02 1999 06 04 1999 © 1999 by Company of Biologists 1999 SOP Microchaete Macrochaete Axon outgrowth Drosophila Prospero Sense organ...

... sensory axon morphology in C. elegans . A class of mutants with deformed sensory cilia at their dendrite endings have extra axon branches, suggesting that sensory deprivation disrupts axon outgrowth. Mutations that alter calcium channels or membrane potential cause similar defects. Cell-specific...

... of these target tissues in vitro. Furthermore, the growth of corticofugal axons is oriented toward an ectopic source of netrin-1 in vitro, and a function blocking anti-netrin-1 antiserum specifically abolishes the cortical axon outgrowth elicited by explants of lateral GE and the ISS in collagen gel cocultures...

... sheath cell monoclonal antibody immunoglobulin superfamily GPI-linked axon outgrowth insect The generation of cellular diversity during neuronal development is an important prerequisite for establishing the complex cellular connections necessary for nervous system function. The stereotypy...

... restricted to a subset of axons later in development. This expression is unique among known insect neurogenic genes and suggests a role for Lachesin in early neuronal differentiation and axon outgrowth. Grasshopper Lachesin is a 38×10 3 M r protein linked to cell membranes through a glycosyl...

... 1992 by Company of Biologists 1992 neural cell adhesion molecule regulation of cell interactions adhesive preferences axon outgrowth Being the first cell adhesion molecule to be identified in vertebrate embryos, NCAM tended to be considered as a candidate receptor in nearly every...

... pathfinding monoclonal antibody axon outgrowth insect. The stereotyped complexity of the central nervous system demands precise instructions to ensure that the correct neuronal connections are formed during development. There are at least two different types of environments present in the embryonic...